Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain
Summary
Acute cannabis administration is reported to alleviate HIV neuropathic pain (HIV-NP), but there is limited knowledge about the effects of cannabis constituents (delta-9 tetrahydrocannabinol/THC and cannabidiol/CBD), the consequences of long-term cannabis use, and the impact of cannabis on endocannabinoid (EC) function in people living with HIV- NP. Our objective is to address these three fundamental gaps in our knowledge by: 1) examining the acute effects of various CBD/THC products on HIV-NP, 2) utilizing a mHealth text messaging protocol, Individual Monitoring of Pain and Cannabis Taken (IMPACT) to monitor daily real-world cannabis use and changes in pain; and 3) studying the relationship between cannabinoids, EC biomarkers, and chronic neuropathic pain
Timeline
- Start
- 2018-07-01
- Primary completion
- 2022-12-31
- Completion
- 2022-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 0.01 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 0.49 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 1.4 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 1.9 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 3.11 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 3.49 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 3.74 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 4.17 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 5.1 % | Inhaled |
| Comparator | Cannabis | Traditional medicine (herbal / TCM) | 15.76 % | Inhaled |