drugset / Trial / NCT03105375
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of X842 in Human: A Single/Multiple Ascending Dose Study
Non-randomizedSequentialOpen-labelBasic science
Summary
The purpose of this study is to assess and analyze the safety, tolerability and PK/PD data following single ascending and multiple ascending doses of X842 in healthy subjects.
Timeline
- Start
- 2017-02-21
- Primary completion
- 2017-10-12
- Completion
- 2017-10-12
Publications
- Background Andersson K, Carlsson E. Potassium-competitive acid blockade: a new therapeutic strategy in acid-related diseases. Pharmacol Ther. 2005 Dec;108(3):294-307. doi: 10.1016/j.pharmthera.2005.05.005. Epub 2005 Jul 5.
- Background Hunt RH, Scarpignato C. Potassium-Competitive Acid Blockers (P-CABs): Are They Finally Ready for Prime Time in Acid-Related Disease? Clin Transl Gastroenterol. 2015 Oct 29;6(10):e119. doi: 10.1038/ctg.2015.39.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Linaprazan glurate | Small molecule | — | — |
| Comparator | Omeprazole | Other / unclassified | — | Oral |
Indications
No indication recorded.