Estimation of Paracetamol in Urine to Assess the Diurnal Variation

Completed 46 enrolled Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Non-randomizedParallel-groupOpen-labelDiagnostic

Summary

Paracetamol is an antipyretic drug that is taken orally at different times of the day in same dose. It is excreted mainly through renal route which may show diurnal variation. In this study, urinary excretion of paracetamol of 41 healthy men of same age group will be measured by HPLC after oral administration of 500 mg paracetamol tablet at morning, midday and night. The measured values will be compared in order to adjust doses of oral paracetamol at different times of the day.

Timeline

Start: 2016-11-03
Primary completion: 2018-01-30
Completion: 2018-01-30

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetaminophen	Small molecule	500 mg	Oral

Indications

No indication recorded.