drugset / Trial / NCT03139370

Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers

NCT03139370 ↗

Phase 1 Terminated 16 enrolled Kite, A Gilead Company
NaSingle-groupOpen-labelTreatment

Summary

The primary objectives of Phase 1A are to evaluate the safety of KITE-718, determine a recommended Phase 1B dose, and to evaluate the efficacy of KITE-718 in Phase 1B.

Timeline

Start
2017-12-27
Primary completion
2021-06-30
Completion
2023-06-04

Outcome

Outcome not reported

Stopped: “The study was terminated due to the sponsor's decision to discontinue the clinical trial.”

Drugs

EvaluationDrugModalityDoseRoute
Subject KITE-718 Cell therapy — —
Background Cyclophosphamide Other / unclassified — Intravenous
Background Fludarabine Small molecule — Intravenous

Indications