Testing Atezolizumab Alone or Atezolizumab Plus Bevacizumab in People With Advanced Alveolar Soft Part Sarcoma

Summary

This phase II trial studies how well atezolizumab or atezolizumab plus bevacizumab works in treating patients with alveolar soft part sarcoma that has not been treated, has spread from where it started to other places in the body (advanced) and cannot be removed by surgery (unresectable). Atezolizumab works by unblocking the immune system, allowing the immune system cells to recognize and then attack tumor cells. Bevacizumab works by controlling the growth of new blood vessels. Giving atezolizumab alone or atezolizumab with bevacizumab may shrink the cancer.

Timeline

Start

2017-04-25

Primary completion

2026-10-31

Completion

2026-10-31

Publications

• Chen AP, Rosenberger CL, Moore N, Foster JC, Naqash AR, Sharon E, O'Sullivan Coyne G, Schwartz GK, Riedel RF, Glod J, Hu JS, Conley AP, Read WL, Burgess MA, Davis EJ, Merriam P, Deshpande HA, Ladle BH, Okuno SH, Beck JC, Chen JL, Ferry-Galow KV, Fino KK, Miller BL, Wilsker DF, Begum A, Parchment RE, Doroshow JH. Atezolizumab for Alveolar Soft Part Sarcoma: A Clinical Trial Update. J Clin Oncol. 2026 Jun;44(16):1490-1497. doi: 10.1200/JCO-25-02811. Epub 2026 Apr 18.
• Chen AP, Sharon E, O'Sullivan-Coyne G, Moore N, Foster JC, Hu JS, Van Tine BA, Conley AP, Read WL, Riedel RF, Burgess MA, Glod J, Davis EJ, Merriam P, Naqash AR, Fino KK, Miller BL, Wilsker DF, Begum A, Ferry-Galow KV, Deshpande HA, Schwartz GK, Ladle BH, Okuno SH, Beck JC, Chen JL, Takebe N, Fogli LK, Rosenberger CL, Parchment RE, Doroshow JH. Atezolizumab for Advanced Alveolar Soft Part Sarcoma. N Engl J Med. 2023 Sep 7;389(10):911-921. doi: 10.1056/NEJMoa2303383.

Drugs

Indications