Food Effect Study of ModraDoc006 in Combination With Ritonavir

Summary

This study aims to evaluate the effect of food on the pharmacokinetics of ModraDoc006 in combination with ritonavir, in an open-label, cross-over design. Patients will be randomized into two treatment groups receiving ModraDoc006/r week 1 under fasting and week 2 under fed condition, or vice versa.

Timeline

Start

2017-05-10

Primary completion

2018-04-04

Completion

2018-04-04

Publications

• Vermunt MAC, de Weger VA, Janssen JM, Lopez-Yurda MI, Keessen M, Thijssen B, Rosing H, Huitema ADR, Beijnen JH, Marchetti S. Effect of Food on the Pharmacokinetics of the Oral Docetaxel Tablet Formulation ModraDoc006 Combined with Ritonavir (ModraDoc006/r) in Patients with Advanced Solid Tumours. Drugs R D. 2021 Mar;21(1):103-111. doi: 10.1007/s40268-020-00336-x. Epub 2021 Jan 19.

Drugs

Indications