drugset / Trial / NCT03169348

The Effect of Direct Antiviral Therapy on Hepatitis c Virus-related Thrombocytopenia

NCT03169348

Unknown 50 enrolled Assiut University
NaSingle-groupOpen-labelTreatment

Summary

Autoimmune thrombocytopenic purpura is an immunological disorder characterized by increased platelet destruction due to presence of anti-platelet antibodies. Hepatitis C virus infection, which is one of the most common chronic viral infections worldwide, may cause secondary chronic immune thrombocytopenic purpura. It seemed to play a pathogenic role in autoimmune thrombocytopenic purpura. Moreover, the successful response (negative hepatitis C virus - ribonucleic acid) to tapered steroids and antiviral therapy was useful to revert thrombocytopenia

Timeline

Start
2017-11-01
Primary completion
2019-06
Completion
2019-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Daclatasvir Small molecule Oral
Subject Ledipasvir/sofosbuvir Unknown Oral
Subject Sofosbuvir Small molecule Oral