Are Paraspinous Intramuscular Injections of Botulinum Toxin A (BoNT-A) Efficient in the Treatment of Chronic Low-back Pain (LBP)?

Summary

Studying the therapeutic effect of paravertebral injections of BoNT-A (botulinum toxin A) requires further studies to confirm the reported short-term therapeutic effect and to determine potential predictive factors of efficacy.

Timeline

Start

2003-11-18

Primary completion

2005-05-05

Completion

2005-05-08

Outcome

Missed primary endpoint

paper There was no significant difference between the groups' average LBP during the last 8 days at Day30 (p = 0.97). PMID 29141611 ↗

paper Injections of BoNT-A in the paravertebral muscles were not found to be effective to relieve chronic LBP. PMID 29141611 ↗

Publications

• Background Foster et al., 2001 and Machado et al., 2016
• Cogne M, Petit H, Creuze A, Liguoro D, de Seze M. Are paraspinous intramuscular injections of botulinum toxin a (BoNT-A) efficient in the treatment of chronic low-back pain? A randomised, double-blinded crossover trial. BMC Musculoskelet Disord. 2017 Nov 15;18(1):454. doi: 10.1186/s12891-017-1816-6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Botulinum toxin type A	Protein / enzyme biologic	200 iu	Intramuscular

Indications