drugset / Trial / NCT03181828

Manipulating the Gut Microbiome Study

NCT03181828 ↗

Phase 1/2 Terminated 4 enrolled Nicholas Ah Mew
RandomizedCrossoverOpen-labelTreatment

Summary

The objective is to determine if acetohydroxamic acid (AHA) can prevent hydrolysis of urea by inhibiting the bacterial urease of gut flora of both healthy control adults as well as adults with urea cycle disorders

Timeline

Start
2017-03-24
Primary completion
2018-06-05
Completion
2018-06-05

Outcome

Outcome not reported

Stopped: “The incidence of AEs was higher than the IB reported.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Acetohydroxamic Acid Small molecule 60 mg/kg Oral

Indications