AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA

Summary

The investigators aimed to evaluate the effect of AMCPR (Augmented-Medication CardioPulmonary Resuscitation: administration of additional vasopressin to titrate to arterial diastolic blood pressure over 20 mmHg) on cardiopulmonary resuscitation results and outcomes in out-of-hospital cardiac arrest patients.

Timeline

Start

2017-12-31

Primary completion

2021-08-31

Completion

2021-08-31

Publications

• Kim JS, Kim YJ, Hong SI, Kim SM, Chae B, Ryoo SM, Kim WY. Diastolic blood pressures and end tidal carbon dioxides during cardiopulmonary resuscitations and their association with outcomes in adult out-of-hospital cardiac arrest patients: A preplanned secondary analysis of the Augmented Medication CardioPulmonary resuscitation (AMCPR) trial. Resuscitation. 2025 May;210:110537. doi: 10.1016/j.resuscitation.2025.110537. Epub 2025 Feb 12.
• Oh DK, Kim JS, Ryoo SM, Kim YJ, Kim SM, Hong SI, Chae B, Kim WY. Augmented-Medication CardioPulmonary Resuscitation (AMCPR) trial: a study protocol for a randomized controlled trial. Clin Exp Emerg Med. 2022 Dec;9(4):361-366. doi: 10.15441/ceem.22.367. Epub 2022 Nov 2.

Drugs

Indications