Drugs / Vasopressin
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Vasopressin

Peptide targets AVPR1A

Developed for
infectious disease with sepsis · cardiac arrest · acute kidney injury · hypotensive disorder · leiomyoma · placenta praevia · arterial disorder · autism
+17 more · autism spectrum disorder · essential hypertension · hemorrhagic disease · liver failure · pelvic organ prolapse · pulmonary arterial hypertension · pulmonary hypertension · schizophrenia · uterine disorder · vascular insufficiency disorder · cirrhosis of liver · heart disorder · heart failure · hypertensive disorder · post-cardiac arrest syndrome · submucous uterine fibroid · traumatic brain injury
Investigated by
University of Electronic Science and Technology of China · National Institute of Mental Health (NIMH) · Stanford University · Asan Medical Center · Emory University · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
+67 more · Hebrew University of Jerusalem · Hospital do Coracao · University of Alberta · University of Athens · University of California, Los Angeles · University of Roma La Sapienza · University of Sao Paulo · University of Thessaly · Al-Azhar University · Allama Iqbal Medical College · Antonios Likourezos · Ascher-Walsh, Charles, M.D. · Assistance Publique - Hôpitaux de Paris · Assistance Publique Hopitaux De Marseille · Aswan University Hospital · Azienda Usl di Bologna · Bowdoin College · Brazilian Research In Intensive Care Network · Canadian Critical Care Trials Group · Canadian Institutes of Health Research (CIHR) · Centre Hospitalier Universitaire Dijon · Children's Medical Center Dallas · Endo USA Inc., a Keenova Therapeutics Company · European Society of Intensive Care Medicine · Federal University of São Paulo · Fondation Hôpital Saint-Joseph · Fonds de la Recherche en Santé du Québec · Francois Lamontagne · Hadassah Medical Organization · Hadassah Medical Organization · Hangang Sacred Heart Hospital · Hospices Civils de Lyon · Hospital Santa Casa de Misericórdia de Vitória · Hospital Universitário Cassiano Antônio de Moraes/HUCAM · James K. Rilling, PhD · Jason Sperry · Jennifer Cutler · John Templeton Foundation · King's College Hospital NHS Trust · Lars Wiuff Andersen · MOUNT SINAI HOSPITAL · MaineHealth · Medical College of Wisconsin · Medical University of South Carolina · National Institute of Mental Health and Neuro Sciences, India · National Institute of Science and Technology (INCT) in Precision Intensive Care Medicine · National Taiwan University Hospital · Peking Union Medical College Hospital · Royal Centre for Defence Medicine · Sahlgrenska University Hospital · Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Seoul National University Hospital · São Paulo Research Foundation · The Cleveland Clinic · The University of Texas Health Science Center at San Antonio · The University of Texas Health Science Center, Houston · The University of Texas Medical Branch, Galveston · Thomas Jefferson University · United States Department of Defense · University Hospital, Clermont-Ferrand · University Hospitals Cleveland Medical Center · University of Aarhus · University of Maryland, Baltimore · University of Sherbrooke · University of Texas Southwestern Medical Center · Wake Forest University Health Sciences · Yonsei University

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) VASOSTRICT — 2014-04-17 fda.gov ↗

Trials 68 · started per year

today
US approved 2014
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 05 trials
Phase 0 NCT04463394 Aug 2020 → Feb 2022 Fontan-associated liver disease, hypotensive disorder Stanford University Completed No outcome recorded
Phase 0 NCT02993640 Sep 2016 → Mar 2017 portal hypertension Sahlgrenska University Hospital Completed No outcome recorded
Phase 0 NCT02394054 Jan 2015 → Jul 2016 — University of California, Los Angeles Completed No outcome recorded
Phase 0 NCT01680718 Oct 2012 → Sep 2013 — University of California, Los Angeles Completed No outcome recorded
Phase 0 NCT00420407 Feb 2007 → Apr 2009 — The University of Texas Health Science Center at San Antonio Terminated No outcome recorded Stop: Enrollment
Phase 15 trials
Phase 1 NCT05738148 Nov 2023 → Jan 2026 overdue cardiac arrest University of Alberta Active not recruiting No outcome recorded
Phase 1 NCT04093050 Oct 2019 → Apr 2021 — Endo USA Inc., a Keenova Therapeutics Company Completed No outcome recorded
Phase 1 NCT01327027 Sep 2011 → Dec 2015 — Bowdoin College Completed No outcome recorded
Phase 1 NCT01093768 Feb 2010 → Apr 2013 autism spectrum disorder National Institute of Mental Health (NIMH) Completed No outcome recorded
Phase 1 NCT00628550 Apr 2008 → Oct 2010 cardiac arrest University of Texas Southwestern Medical Center Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03446456 Sep 2018 → Sep 2026 overdue — University of Maryland, Baltimore Recruiting No outcome recorded
Phase 27 trials · 1 met primary
Phase 2 NCT07614438 Aug 2026 overdue chronic thromboembolic pulmonary hypertension Fondation Hôpital Saint-Joseph Not yet recruiting No outcome recorded
Phase 2 NCT06547892 Apr → Oct 2025 overdue — Hospital do Coracao Recruiting No outcome recorded
Phase 2 NCT05958342 Jun 2024 → Mar 2027 expected hemorrhagic disease Jason Sperry Recruiting No outcome recorded
Phase 2 NCT03191240 Dec 2017 → Aug 2021 cardiac arrest Asan Medical Center Completed No outcome recorded
Phase 2 NCT01370096 Feb 2012 → Sep 2016 pulmonary hypertension University of Alberta Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT00481572 Jan → Dec 2007 infectious disease with sepsis University of Roma La Sapienza Completed No outcome recorded
Phase 2 NCT00411879 Jun 2006 → Apr 2007 cardiac arrest University of Athens Completed Met primary
Phase 2/37 trials · 2 met primary · 1 missed
Phase 2/3 NCT03483753 Jan 2019 → Oct 2023 — University of Sao Paulo Withdrawn Met primary Stop: Business
Phase 2/3 NCT03640949 Sep 2018 → Jan 2021 cardiac arrest Lars Wiuff Andersen Completed Met primary
Phase 2/3 NCT03204786 Feb 2018 → Mar 2024 autism Stanford University Completed No outcome recorded
Phase 2/3 NCT03088345 Mar 2017 → Nov 2018 congenital heart disease, univentricular heart, vascular insufficiency disorder Medical College of Wisconsin Completed No outcome recorded
Phase 2/3 NCT02975999 Dec 2016 → Dec 2019 univentricular heart Wake Forest University Health Sciences Completed No outcome recorded
Phase 2/3 NCT00995839 Nov 2008 → Feb 2010 infectious disease with sepsis University of Roma La Sapienza Completed Missed primary
Phase 2/3 NCT00269685 Jul 2000 → ? — University of Sherbrooke Completed No outcome recorded
Phase 36 trials · 1 met primary
Phase 3 NCT07423156 Mar → Aug 2026 overdue placenta praevia Allama Iqbal Medical College Not yet recruiting No outcome recorded
Phase 3 NCT07052084 Jan 2026 → Feb 2028 expected infectious disease with sepsis Assistance Publique Hopitaux De Marseille Not yet recruiting No outcome recorded
Phase 3 NCT06344442 Apr → May 2025 overdue acute kidney injury Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 3 NCT06464510 Nov 2024 → Aug 2027 expected infectious disease with sepsis Hospital do Coracao Recruiting No outcome recorded
Phase 3 NCT05568160 Jan 2023 → Mar 2026 overdue — Centre Hospitalier Universitaire Dijon Active not recruiting No outcome recorded
Phase 3 NCT00729794 Sep 2008 → Nov 2010 cardiac arrest University of Athens Completed Met primary
Phase 414 trials · 1 met primary · 1 missed
Phase 4 NCT07633600 Jun 2026 → Jun 2027 expected — Jennifer Cutler Not yet recruiting No outcome recorded
Phase 4 NCT06709573 Apr 2025 → May 2027 expected infectious disease with sepsis The Cleveland Clinic Recruiting No outcome recorded
Phase 4 NCT06419075 Jul 2024 → Jan 2025 pelvic organ prolapse The University of Texas Medical Branch, Galveston Withdrawn No outcome recorded
Phase 4 NCT06471231 May 2024 → May 2026 impaired renal function disease, infectious disease with sepsis Azienda Usl di Bologna Unknown No outcome recorded
Phase 4 NCT06934798 Apr 2024 → Jul 2025 overdue arterial disorder University of Sao Paulo Recruiting No outcome recorded
Phase 4 NCT06290596 Apr → Oct 2024 uterine disorder Al-Azhar University Unknown No outcome recorded
Phase 4 NCT06265259 Dec 2023 → Dec 2025 — University of Thessaly Unknown No outcome recorded
Phase 4 NCT05886192 May 2023 → Jan 2025 infectious disease with sepsis Peking Union Medical College Hospital Unknown No outcome recorded
Phase 4 NCT04935814 Jun 2021 → Aug 2022 — University Hospital, Clermont-Ferrand Completed No outcome recorded
Phase 4 NCT04602767 Oct 2020 → May 2024 acute kidney injury Thomas Jefferson University Unknown No outcome recorded
Phase not applicable23 trials
— NCT07838493 Sep → Dec 2026 expected — University of Electronic Science and Technology of China Recruiting No outcome recorded
— NCT06605300 Oct 2024 → Jul 2025 — University of Electronic Science and Technology of China Completed No outcome recorded
— NCT06203847 Jul 2024 → Jul 2026 overdue cardiac arrest National Taiwan University Hospital Recruiting No outcome recorded
— NCT06329063 Mar 2024 → Jun 2025 — University of Electronic Science and Technology of China Unknown No outcome recorded
— NCT06329037 Mar 2024 → Jun 2025 — University of Electronic Science and Technology of China Unknown No outcome recorded
— NCT06234592 Jan 2024 → Jan 2026 overdue acute kidney injury, infectious disease with sepsis King's College Hospital NHS Trust Recruiting No outcome recorded
— NCT04890470 Mar 2021 → Dec 2022 — University of Electronic Science and Technology of China Completed No outcome recorded
— NCT04493554 Jul → Nov 2020 — University of Electronic Science and Technology of China Completed No outcome recorded
— NCT04214145 Jan 2020 → Sep 2021 — Seoul National University Hospital Completed No outcome recorded
— NCT04170751 Nov 2019 → Sep 2021 essential hypertension Yonsei University Unknown No outcome recorded
Comparator or background therapy36 trials
Phase 2 NCT06302998 Comparator Jun 2024 → Dec 2025 infectious disease with sepsis Mansoura University Unknown No outcome recorded
Phase 2 NCT07446933 Comparator Mar 2024 → Oct 2025 — Zagazig University Completed No outcome recorded
Phase 2 NCT01962870 Comparator Dec 2013 → May 2017 autism spectrum disorder Stanford University Completed No outcome recorded
Phase 2 NCT01611935 Comparator May 2013 → Sep 2016 — University of Pennsylvania Completed No outcome recorded
Phase 2 NCT01247090 Comparator Oct 2010 → Aug 2018 end stage renal failure, hypertensive disorder Columbia University Completed No outcome recorded

News releases announcing trial results or a regulatory action · 3

DateIssuerRelease
2022-08-11 Impax Laboratories, LLC Regulatory Amneal launches 4 new Generic products, including Vasopressin single-dose amneal.com ↗
Amneal Pharmaceuticals, Inc. (NYSE: AMRX) (“Amneal” or the “Company”) today announced that it has received Abbreviated New Drug Application (ANDA) approval from the U.S. Food and Drug Administration (“FDA”) for four generics products, including vasopressin injection 1mL (single-dose).
2022-07-19 Amphastar Pharmaceuticals, Inc. Regulatory Amphastar Receives FDA Approval for Vasopressin amphastar.com ↗
Amphastar Pharmaceuticals, Inc. (NASDAQ:AMPH) announced that the U.S. Food and Drug Administration ("FDA") has approved the Company's Abbreviated New Drug Application ("ANDA") for Vasopressin injection, USP 20 Units/mL, 1mL Single Dose Vial.
2021-12-29 Amphastar Pharmaceuticals, Inc. Regulatory Amphastar Receives FDA Tentative Approval for Vasopressin amphastar.com ↗
Amphastar Pharmaceuticals, Inc. (NASDAQ:AMPH) announced that the U.S. Food and Drug Administration ("FDA") has tentatively approved the Company's Abbreviated New Drug Application ("ANDA") for Vasopressin injection, USP 20 Units/mL, 1mL Single Dose Vial.

Evidence & citations 14 cited values

Every value below carries the sentence it was read from. 111 sources stand behind the page.

FieldValueCited text
Known as Vasopressin “Injection of Vasopressin into the uterine tissue surrounding fibroids constricts blood vessels, and has been found to be beneficial by decreasing blood flow to fibroids, and...” NCT03815344 ↗
95

“Mean arterial pressure (MAP) will be increased from 65 mmHg to 85 mmHg with a blind drug (Vasopressin at 0.03 IU/min). If MAP does not increase norepinephrine will be titrated...” NCT06125184 ↗

“Protocol-directed vasopressor administration based on hemodynamic monitoring data. Agents included norepinephrine, phenylephrine, epinephrine, dopamine, and vasopressin.” NCT02742974 ↗

“The investigators will use vasopressin as the primary vasopressor and a heart rate-calibrated dexmedetomidine infusion in septic shock patients.” NCT06302998 ↗

“Arginine vasopressin (AVP), an essential stress hormone released in response to hypotension” NCT06344442 ↗

“Using Vasopressin \[20 IU/CPR cycle\] injection until the 5th cycle” NCT03317197 ↗

“Vasostrict® (vasopressin injection, USP)” NCT04093050 ↗

“vasopressin (Pitressin® 20Unints/vial)” NCT06203847 ↗

“vasopressin” NCT06709573 ↗

“vasopressin” NCT01800877 ↗

“Vasopressin” NCT07633600 ↗

Show 85 more sources

Known as arginine vasopressin “Adult in-patients with cardiac arrest not responsive to two direct current countershocks (when applicable) or asystole or pulseless electrical activity are randomized to...” NCT00411879 ↗
13

“The neuropeptides arginine vasopressin and oxytocin play key roles in socioemotional processes such as pair bonding and parental care” PMID 25462898 ↗ Oct 2014

“Arginine vasopressin (AVP) and related peptides have diverse effects on social behaviors in vertebrates” PMID 29018407 ↗ Sep 2017

“The hormone arginine vasopressin (AVP), in particular, may prove a useful adjunct during resuscitation.” NCT01611935 ↗

NCT00127907 ↗

NCT06344442 ↗

NCT01296269 ↗

NCT05920707 ↗

NCT01318278 ↗

NCT05439460 ↗

NCT00995839 ↗

Show 3 more sources

Known as argipressin “Vasopressin is commercially available under the name "argipressin".” NCT04935814 ↗
Known as AVP “The present study was designed to determine the effects of continuously infused norepinephrine (NE) plus (1) terlipressin (TP) or (2) arginine vasopressin (AVP) or (3) placebo...” PMID 21929764 ↗ Sep 2011
13

“The main aim of the present study is to investigate the effects of orally administered vasopressin (AVP) on bottom-up and top-down attentional control to socio-emotional stimuli” NCT06329037 ↗

“Although potential links between oxytocin (OT), vasopressin (AVP), and social cognition are well-grounded theoretically” PMID 37310308 ↗ Oct 2021

“addition of vasopressin (AVP), a drug used as a vasopressor but with cathecholamine independent mechanisms” NCT06125184 ↗

“A single dose of 24 IU arginine vasopressin (AVP) is administered via a lyophilized oromucosal lollipop.” NCT07838493 ↗

“The hormone arginine vasopressin (AVP), in particular, may prove a useful adjunct during resuscitation.” NCT01611935 ↗

“Arginine vasopressin (AVP) and related peptides have diverse effects on social behaviors in vertebrates” PMID 29018407 ↗ Sep 2017

“Vasopressin (AVP) is commonly added to norepinephrine (NE) to reverse shock in patients with sepsis.” PMID 29784057 ↗ May 2018

“Arginine vasopressin (AVP), an essential stress hormone released in response to hypotension” NCT06344442 ↗

“the neuropeptide oxytocin (OXT) and vassopressin (AVP) influence moral decision making” NCT04890470 ↗

“Oxytocin (OT) and vasopressin (AVP) have been shown to improve social cognition” PMID 27053769 ↗ Apr 2016

Show 3 more sources

Known as D-arginine-D-vasopressin “Vasopressin (D-arginine-D-vasopressin) is an endogenous hormone synthesized by the hypothalamus” NCT04935814 ↗
Known as Empressin “20 IU of vasopressin (Empressin®, Amomed Pharma GmbH)” NCT03640949 ↗
Known as Pitressin “Adult in-patients with cardiac arrest not responsive to two direct current countershocks (when applicable) or asystole or pulseless electrical activity are randomized to...” NCT00411879 ↗
1

“vasopressin (Pitressin® 20Unints/vial)” NCT06203847 ↗

Known as Vasopressin (Vasostrict) (Par Pharmaceutical, Chestnut Ridge, NY). “Vasopressin (Vasostrict) (Par Pharmaceutical, Chestnut Ridge, NY).” NCT06419075 ↗
Known as Vasopressins “Drug: Vasopressins” NCT03191240 ↗
Known as Vasostrict “Vasopressin (USP) Injectable Solution [Vasostrict]” NCT03204786 ↗
1

“Vasostrict® (vasopressin injection, USP)” NCT04093050 ↗

Action Activate “vasopressin receptor agonists terlipressin and vasopressin” NCT00995839 ↗
Modality Peptide “The goal of this protocol, broadly stated, is to evaluate the effects of the neuropeptides oxytocin and vasopressin on the neural systems involved in social cognition and...” NCT01093768 ↗
Route Intravenous “intravenous adrenaline (1mg) or vasopressin (40 IU) at ED” PMID 22353644 ↗ Feb 2012
Target AVPR1A “binds to AVPR1a to promote vasoconstriction” NCT06344442 ↗