drugset / Trial / NCT06464510
Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis
Phase 3
Recruiting
2800 enrolled
Hospital do Coracao
Brazilian Research In Intensive Care Network · collabNational Institute of Science and Technology (INCT) in Precision Intensive Care Medicine · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The norepinephrine and vasopressin for rescue versus early vasopressin for vasopressor dependent sepsis (NoVa) is a phase 3, multicenter, open-label, randomized controlled trial comparing an early vasopressin initiation strategy versus norepinephrine plus vasopressin initiation only as a rescue strategy for hemodynamic management of critically ill patients with vasopressor dependent sepsis.
Timeline
- Start
- 2024-11-21
- Primary completion
- 2027-08
- Completion
- 2027-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Norepinephrine | Other / unclassified | — | — |
| Subject | Vasopressin | Peptide | 0.04 iu | — |