Vasopressin for Septic Shock Pragmatic Trial

Summary

Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure. Sometimes first-line vasopressors are inadequate, prompting addition of a second-line vasopressor called vasopressin. However, the threshold at which to start vasopressin remains unclear. This pragmatic, cluster-randomized, cluster-crossover trial will evaluate two different strategies for septic shock treatment commonly used in current practice, comparing a lower versus a higher threshold for adding vasopressin to first-line vasopressors.

Timeline

Start

2024-02-01

Primary completion

2026-07

Completion

2027-12

Publications

• Peltan ID, Groat D, Jacobs JR, Tillman EH, Brintz BJ, Chauv S, Beesley SJ, Edwards JH, Arizmendez N, Hirshberg EL, Carr JR, Lanspa MJ, Bledsoe JR, Smith AT, Schneider H, Hu P, Moores Todd TD, Klippel C, Semler MW, Casey JW, Grissom CK, Brown SM, Leither LM. Protocol and Statistical Analysis Plan for the Vasopressin for Septic Shock Pragmatic (VASSPR) Cluster-Crossover Randomized Trial. CHEST Crit Care. 2025 Dec;3(4):100178. doi: 10.1016/j.chstcc.2025.100178. Epub 2025 Nov 12.

Drugs

Indications