Serum Serotonin and Pruritus After Intrathecal Morphine in Cesarean Section

NCT03209427 ↗

Phase 4 Completed 40 enrolled Assiut University

RandomizedParallel-groupSingle-blindDiagnostic

Summary

Pruritus is the commonest side effect of intrathecal morphine especially in parturient, but the exact mechanism of pruritus is not clear. Many mechanisms have been suggested. Among these mechanisms is the activation of the 5-HT3 receptors by the intrathecally injected morphine.

Timeline

Start: 2014-04-02
Primary completion: 2015-04-30
Completion: 2016-09-21

Publications

Results Bonnet MP, Marret E, Josserand J, Mercier FJ. Effect of prophylactic 5-HT3 receptor antagonists on pruritus induced by neuraxial opioids: a quantitative systematic review. Br J Anaesth. 2008 Sep;101(3):311-9. doi: 10.1093/bja/aen202. Epub 2008 Jul 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Morphine	Other / unclassified	100 ug	Intrathecal
Comparator	Morphine	Other / unclassified	200 ug	Intrathecal

Indications

No indication recorded.