drugset / Trial / NCT03221400
PEN-866 in Patients With Advanced Solid Malignancies
Non-randomizedSingle-groupOpen-labelTreatment
Summary
Protocol PEN-866-001 is an open-label, multi-center, first-in-human Phase 1/2a study evaluating PEN-866 in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.
Timeline
- Start
- 2017-08-29
- Primary completion
- 2023-01
- Completion
- 2023-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | PEN-866 | Other / unclassified | — | Intravenous |
| Background | Leucovorin | Small molecule | 400 mg/m2 | Intravenous |
| Background | Niraparib | Small molecule | — | — |
| Background | fluorouracil | Small molecule | 2400 mg/m2 | Intravenous |