Drugs / Niraparib
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Niraparib

Small molecule targets PARP1, PARP2 via inhibition

Developed for
ovarian cancer · ovarian carcinoma · ovarian neoplasm · fallopian tube cancer · cancer · primary peritoneal carcinoma · breast cancer · BRCA1-related cancer predisposition
+102 more · BRCA2-related cancer predisposition · castration-resistant prostate carcinoma · metastatic malignant neoplasm · female breast carcinoma · glioblastoma · malignant pancreatic neoplasm · metastatic prostate carcinoma · neoplasm · triple-negative breast carcinoma · endometrial carcinoma · small cell lung carcinoma · PALB2-related cancer predisposition · prostate adenocarcinoma · prostate carcinoma · urothelial carcinoma · breast neoplasm · cholangiocarcinoma · endometrial cancer · fallopian tube carcinoma · head and neck cancer · head and neck squamous cell carcinoma · Her2-receptor negative breast cancer · pancreatic ductal adenocarcinoma · peritoneum cancer · serous neoplasm · ATM-related cancer predisposition · biliary tract cancer · cervical carcinoma · colorectal cancer · endometrial serous adenocarcinoma · endometrium adenocarcinoma · esophageal cancer · female reproductive organ cancer · gastric adenocarcinoma · gastric cancer · HER2 positive breast carcinoma · hormone receptor-positive breast cancer · lung cancer · malignant glioma · malignant mesothelioma · melanoma · mesothelioma · non-small cell lung carcinoma · ovarian serous adenocarcinoma · pancreatic adenocarcinoma · prostate cancer · prostate neoplasm · soft tissue sarcoma · adenocarcinoma · astrocytoma (excluding glioblastoma) · B-cell chronic lymphocytic leukemia · biliary tract neoplasm · brain glioblastoma · breast carcinoma · cancer of unknown primary site · carcinoma · central nervous system cancer · cervical cancer · clear cell renal carcinoma · colorectal carcinoma · endometrioid adenocarcinoma · Ewing sarcoma · fallopian tube neoplasm · gastroesophageal adenocarcinoma · hereditary breast carcinoma · hereditary neoplastic syndrome · hereditary site-specific ovarian cancer syndrome · hormone-resistant prostate carcinoma · invasive breast carcinoma · leiomyosarcoma · low grade glioma · lung neoplasm · malignant colon neoplasm · malignant epithelial tumor of ovary · malignant urinary system neoplasm · mantle cell lymphoma · metastatic carcinoma in the bone · metastatic malignant neoplasm in the brain · metastatic melanoma · metastatic neoplasm · nasopharyngeal carcinoma · neoplastic disease or syndrome · oligodendroglioma · ovarian adenocarcinoma · ovarian carcinosarcoma · ovarian serous tumor · pancreatic large cell neuroendocrine carcinoma · penile carcinoma · primary brain neoplasm · primary peritoneal serous adenocarcinoma · prostate small cell carcinoma · rectal cancer · refractory malignant neoplasm · renal cell carcinoma · retroperitoneal sarcoma · salivary gland carcinoma · serous adenocarcinoma · T-cell prolymphocytic leukemia · urinary bladder cancer · uterine adnexa cancer · uterine carcinosarcoma · uveal melanoma
Investigated by
GlaxoSmithKline · Tesaro, Inc. · Zai Lab (Shanghai) Co., Ltd. · Janssen Research & Development, LLC · Massachusetts General Hospital · Takeda
+232 more · Janssen, LP · M.D. Anderson Cancer Center · Merck Sharp & Dohme LLC · National Cancer Institute (NCI) · Sun Yat-sen University · Eli Lilly and Company · ARCAGY/ GINECO GROUP · Abramson Cancer Center at Penn Medicine · Bayer · Bristol-Myers Squibb · EMD Serono Research & Development Institute, Inc. · European Network of Gynaecological Oncological Trial Groups (ENGOT) · Hoffmann-La Roche · Merck KGaA, Darmstadt, Germany · Myriad Genetics, Inc. · Oregon Health and Science University · Roche Pharma AG · University Health Network, Toronto · University of Alabama at Birmingham · University of Oklahoma · AstraZeneca · British Lung Foundation · Dana-Farber Cancer Institute · Emory University · European Organisation for Research and Treatment of Cancer - EORTC · Facing Our Risk of Cancer Empowered · Fudan University · Gynecologic Oncology Group · Hunan Cancer Hospital · Ipsen · Ivy Brain Tumor Center · Janssen Scientific Affairs, LLC · Mayo Clinic · MedSIR · Nordic Society of Gynaecological Oncology - Clinical Trials Unit · OHSU Knight Cancer Institute · Peking Union Medical College Hospital · Peking University Cancer Hospital & Institute · Pfizer · The Netherlands Cancer Institute · Tongji Hospital · Translational Breast Cancer Research Consortium · University of California, San Francisco · University of Pennsylvania · University of Turin, Italy · Yonsei University · Zhejiang Cancer Hospital · AGO Research GmbH · Accord Healthcare, Inc. · Amgen · Apices Soluciones S.L. · Armando Santoro, MD · Artios Pharma Ltd · Asan Medical Center · Assistance Publique - Hôpitaux de Paris · Avera McKennan Hospital & University Health Center · Baptist Health South Florida · Barrow Neurological Institute · Belgian Group of Digestive Oncology · BerGenBio ASA · Boehringer Ingelheim · Breast Cancer Research Foundation of Alabama · Breast International Group · Byondis B.V. · CRIS Cancer Foundation · CRO "Centro Clinical Trials" IRCCS Ospedale Policlinico San Martino · California Pacific Medical Center Research Institute · Canadian Cancer Trials Group · CanariaBio Inc. · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Cancer Research UK · Cancer Research UK & UCL Cancer Trials Centre · Cancerfonden · Casey Cosgrove · all 238 on the full record

Regulatory milestones approvals, filings & regulatory actions · 7 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (5) US (FDA) ZEJULA 2019-10-23 – 2025-06-18 fda.gov
Approved EU (EMA) Zejula 2017-11-16 europa.eu
Approved US (FDA) ZEJULA 2017-03-27 fda.gov

Trials 193 · started per year

today
US approved 2017
EU approved 2017
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 04 trials
Phase 0 NCT05289648 May 2024 → Oct 2025 endometrial cancer, serous adenocarcinoma Sir Mortimer B. Davis - Jewish General Hospital Withdrawn No outcome recorded
Phase 0 NCT05406700 May 2023 → Jul 2026 overdue low grade glioma, malignant glioma Massachusetts General Hospital Active not recruiting No outcome recorded
Phase 0 NCT05238831 Jan 2023 → May 2026 female breast carcinoma, ovarian carcinoma, pancreatic ductal adenocarcinoma, pancreatic large cell neuroendocrine carcinoma +2 OHSU Knight Cancer Institute Withdrawn No outcome recorded
Phase 0 NCT05076513 Oct 2021 → Mar 2024 overdue brain glioblastoma Nader Sanai Active not recruiting No outcome recorded
Phase 140 trials
Phase 1 NCT06161493 Jan 2024 → Dec 2026 ovarian cancer Haider Mahdi Withdrawn No outcome recorded
Phase 1 NCT05666349 Oct 2023 glioblastoma University College, London Withdrawn No outcome recorded
Phase 1 NCT05694715 May 2023 → Jan 2028 expected ATM-related cancer predisposition, BRCA1-related cancer predisposition, BRCA2-related cancer predisposition, PALB2-related cancer predisposition +1 University of California, San Francisco Recruiting No outcome recorded
Phase 1 NCT04149145 May 2023 → May 2024 ovarian carcinoma University of Alabama at Birmingham Withdrawn No outcome recorded
Phase 1 NCT04926324 Jul 2022 → Nov 2024 rectal cancer University of Iowa Terminated No outcome recorded
Phase 1 NCT04673448 Oct 2021 → Dec 2025 overdue fallopian tube carcinoma, female breast carcinoma, hereditary breast carcinoma, hereditary neoplastic syndrome +4 University of Washington Active not recruiting No outcome recorded
Phase 1 NCT04991480 Sep 2021 → Dec 2025 breast cancer, metastatic malignant neoplasm Artios Pharma Ltd Completed No outcome recorded
Phase 1 NCT03944902 Sep 2021 → Jan 2022 ovarian cancer University of Alabama at Birmingham Terminated No outcome recorded
Phase 1 NCT04481113 Jun 2021 → Oct 2023 female breast carcinoma, hormone receptor-positive breast cancer, invasive breast carcinoma OHSU Knight Cancer Institute Completed No outcome recorded
Phase 1 NCT04764084 Apr → Nov 2021 Her2-receptor negative breast cancer, cholangiocarcinoma, gastric adenocarcinoma, malignant pancreatic neoplasm Peking University Cancer Hospital & Institute Unknown No outcome recorded
Phase 1/222 trials
Phase 1/2 NCT06682780 Sep 2025 → Dec 2028 expected neoplasm LaNova Medicines Limited Recruiting No outcome recorded
Phase 1/2 NCT06953323 Jul 2025 → Jun 2029 expected neoplasm Wigen Biomedicine Technology (Shanghai) Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT05672095 Apr 2025 → Nov 2026 fallopian tube carcinoma, ovarian carcinoma, primary peritoneal carcinoma City of Hope Medical Center Withdrawn No outcome recorded
Phase 1/2 NCT06329830 Oct 2024 → Oct 2026 castration-resistant prostate carcinoma, metastatic prostate carcinoma Baptist Health South Florida Withdrawn No outcome recorded
Phase 1/2 NCT06594679 Sep 2024 → Mar 2027 expected ovarian cancer Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Recruiting No outcome recorded
Phase 1/2 NCT06258018 Sep 2024 → Dec 2026 expected malignant glioma Armando Santoro, MD Not yet recruiting No outcome recorded
Phase 1/2 NCT05784012 Nov 2023 → Mar 2027 expected head and neck squamous cell carcinoma Spanish Head And Neck Cancer Cooperative Group Active not recruiting No outcome recorded
Phase 1/2 NCT06077877 Oct 2023 → Jun 2026 overdue neoplasm GlaxoSmithKline Active not recruiting No outcome recorded
Phase 1/2 NCT05519670 Mar 2023 → Sep 2027 expected breast cancer Institut Paoli-Calmettes Not yet recruiting No outcome recorded
Phase 1/2 NCT05198804 Jan 2022 → Oct 2025 fallopian tube cancer, ovarian cancer, primary peritoneal carcinoma K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Completed No outcome recorded
Phase 2102 trials
Phase 2 NCT06392841 Oct 2025 → Jan 2028 BRCA1-related cancer predisposition, BRCA2-related cancer predisposition, CHEK2-related cancer predisposition, Fanconi anemia complementation group A +2 Qian Qin Withdrawn No outcome recorded
Phase 2 NCT06747845 May 2025 → Jun 2028 expected pancreatic adenocarcinoma Abramson Cancer Center at Penn Medicine Recruiting No outcome recorded
Phase 2 NCT06527690 Apr 2025 → Sep 2027 castration-resistant prostate carcinoma Latin American Cooperative Oncology Group Withdrawn No outcome recorded
Phase 2 NCT06365970 Jan 2025 → Jan 2027 colorectal cancer Ibrahim Halil Sahin Withdrawn No outcome recorded
Phase 2 NCT06180356 Dec 2024 → Jan 2028 expected ovarian cancer, ovarian serous tumor MedSIR Recruiting No outcome recorded
Phase 2 NCT06433219 Oct 2024 → Jun 2026 overdue ovarian carcinoma EMD Serono Research & Development Institute, Inc. Active not recruiting No outcome recorded
Phase 2 NCT06535893 Jul 2024 → Jun 2027 expected breast cancer Nagoya City University Recruiting No outcome recorded
Phase 2 NCT05990192 Jun 2024 → Dec 2027 expected ovarian carcinoma Institute of Cancer Research, United Kingdom Recruiting No outcome recorded
Phase 2 NCT05689021 Mar 2024 → Jul 2026 overdue castration-resistant prostate carcinoma, prostate adenocarcinoma Mayo Clinic Active not recruiting No outcome recorded
Phase 2 NCT06237205 Feb 2024 → Jun 2026 overdue Korea University Anam Hospital Not yet recruiting No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT04159155 Nov 2020 → May 2025 endometrial carcinoma, serous neoplasm University Health Network, Toronto Terminated No outcome recorded
Phase 2/3 NCT03651206 Jul 2020 → Jun 2027 expected ovarian carcinosarcoma, uterine carcinosarcoma ARCAGY/ GINECO GROUP Recruiting No outcome recorded
Phase 316 trials
Phase 3 NCT05615818 Jul 2024 → Jun 2027 expected biliary tract neoplasm UNICANCER Recruiting No outcome recorded
Phase 3 NCT06388733 Jun 2024 → Dec 2027 expected glioblastoma, primary brain neoplasm Ivy Brain Tumor Center Active not recruiting No outcome recorded
Phase 3 NCT04915755 Jun 2021 → Jun 2024 overdue breast neoplasm GlaxoSmithKline Active not recruiting No outcome recorded
Phase 3 NCT04679064 Dec 2020 → Jan 2025 ovarian cancer Fondazione Policlinico Universitario Agostino Gemelli IRCCS Unknown No outcome recorded
Phase 3 NCT04475939 Oct 2020 → Feb 2025 non-small cell lung carcinoma GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT04497844 Sep 2020 → Jan 2025 overdue metastatic prostate carcinoma Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 3 NCT03806049 Dec 2019 → Dec 2022 ovarian cancer Nordic Society of Gynaecological Oncology - Clinical Trials Unit Withdrawn No outcome recorded
Phase 3 NCT03768063 Feb 2019 → Jul 2028 expected cancer Hoffmann-La Roche Active not recruiting No outcome recorded
Phase 3 NCT03903835 Feb 2019 → Dec 2026 expected castration-resistant prostate carcinoma, metastatic prostate carcinoma Karolinska Institutet Recruiting No outcome recorded
Phase 3 NCT03748641 Jan 2019 → Oct 2021 overdue castration-resistant prostate carcinoma Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 45 trials
Phase 4 NCT06412120 Jun 2026 → Jun 2029 expected ovarian cancer University of Miami Recruiting No outcome recorded
Phase 4 NCT06887933 Apr 2025 → Mar 2026 overdue ovarian neoplasm GlaxoSmithKline Not yet recruiting No outcome recorded
Phase 4 NCT05187208 Jan 2022 → Dec 2025 ovarian carcinoma, uterine adnexa cancer Seoul National University Hospital Unknown No outcome recorded
Phase 4 NCT04861181 May 2021 → Apr 2025 Hospices Civils de Lyon Terminated No outcome recorded
Phase 4 NCT03752216 Apr 2019 → Aug 2021 ovarian cancer ARCAGY/ GINECO GROUP Completed No outcome recorded
Phase not stated2 trials
NCT03025867 ovarian cancer Tesaro, Inc. Approved for marketing No outcome recorded
NCT05401214 prostate carcinoma Janssen Research & Development, LLC Approved for marketing No outcome recorded
Also used as a comparator or background therapy in 10 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT05261269 Background Feb 2022 → Sep 2023 Her2-receptor negative breast cancer Dantari, Inc. Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT04826198 Background Oct 2020 → Apr 2024 ovarian cancer Gustave Roussy, Cancer Campus, Grand Paris Terminated No outcome recorded
Phase 1/2 NCT03221400 Background Aug 2017 → Jan 2023 anal squamous cell carcinoma, cervical squamous cell carcinoma, endometrium adenocarcinoma, gastric adenocarcinoma +5 Tarveda Therapeutics Unknown No outcome recorded
Phase 23 trials
Phase 2 NCT06212583 Comparator Apr 2024 → Dec 2028 expected prostate cancer University of Maryland, Baltimore Active not recruiting No outcome recorded
Phase 2 NCT05641506 Background Dec 2022 → Oct 2023 ovarian cancer Sichuan Cancer Hospital and Research Institute Unknown No outcome recorded
Phase 2 NCT04812366 Comparator Sep 2021 → Apr 2026 overdue prostate cancer University of British Columbia Recruiting No outcome recorded
Phase 34 trials
Phase 3 NCT06915025 Background Jul 2025 → Oct 2032 expected fallopian tube cancer, malignant epithelial tumor of ovary, primary peritoneal carcinoma Imunon Recruiting No outcome recorded
Phase 3 NCT05009082 Comparator Sep 2022 → Dec 2028 expected fallopian tube cancer, ovarian carcinoma, peritoneum cancer AGO Study Group Recruiting No outcome recorded
Phase 3 NCT03981796 Comparator Jul 2019 → Nov 2026 expected neoplasm Tesaro, Inc. Active not recruiting No outcome recorded
Phase 3 NCT01847274 Comparator Jun 2013 → Apr 2016 ovarian neoplasm Tesaro, Inc. Completed No outcome recorded

Press releases naming this drug 1 release

DateIssuerRelease
2017-07-27 Takeda TESARO and Takeda Enter into Exclusive Licensing Agreement to Develop and Commercialize Novel Cancer Therapy Niraparib in Japan takeda.com

Evidence & citations 21 cited values

Every value below carries the sentence it was read from. 207 sources stand behind the page.

FieldValueCited text
Known as Niraparib “This is an open-label, single-arm, Phase 2 study which will evaluate the efficacy and safety of niraparib and dostarlimab (TSR-042) combination in patients with metastatic,...” NCT04983745
197

Niraparib (MK4827) is an oral potent, selective PARP-1 and PARP-2 inhibitor that induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function.” PMID 23810788 Jun 2013

Niraparib plus bevacizumab versus niraparib alone for platinum-sensitive recurrent ovarian cancer (NSGO-AVANOVA2/ENGOT-ov24): a randomised, phase 2, superiority trial.” PMID 31474354 Aug 2019

“A Study of ZL-2306 (Niraparib) as Maintenance Treatment Following First-line Chemotherapy in Patients With Advanced Ovarian Cancer” NCT03709316

“Carboplatin + paclitaxel + pembrolizumab followed by niraparib + pembrolizumab Niraparib Pembrolizumab AC” NCT06535893

“RP-3500 (camonsertib, ATR inhibitor) in combination with niraparib or olaparib (PARP inhibitors)” NCT04972110

“Participants will receive a fixed dose of Niraparib and CB-839, 800mg.” NCT03944902

“Efficacy and Safety of ZL-2306 (Niraparib) in Ovarian Cancer Patient” NCT03705156

niraparib, an orally available small molecule PARP inhibitor” NCT03644342

Niraparib is a PARP inhibitor.” NCT03516084

niraparib 300 mg PO qd” NCT06145308

“ZL-2306 (niraparib)” NCT03551171

NiraparibNCT04817956

NCT05870761

NCT03359850

NCT04423185

NCT04544995

NCT05065021

NCT04159155

NCT05162196

NCT04584255

NCT04475939

NCT03431350

NCT02925234

NCT06915025

NCT05694715

NCT06682780

NCT03016338

NCT05718323

NCT05261269

NCT04673448

NCT04940637

NCT03955471

NCT05615818

NCT05461690

NCT05700721

NCT04217798

NCT03752216

NCT04170153

NCT05751629

NCT03207347

NCT04826198

NCT03497429

NCT05519670

NCT03553004

NCT03651206

NCT06527690

NCT03154281

NCT06329830

NCT05689021

NCT05076513

NCT04030559

NCT04240106

NCT04185831

NCT03574779

NCT02500901

NCT05672095

NCT05641506

NCT04376073

NCT03981796

NCT03209401

NCT01042379

NCT04502602

NCT06953323

NCT06077877

NCT02655016

NCT04641247

NCT05784012

NCT05126342

NCT05990192

NCT02924766

NCT04947254

NCT05311579

NCT04493060

NCT03806049

NCT05297864

NCT04701307

NCT05523440

NCT05406700

NCT04812366

NCT03695380

NCT05601440

NCT04592237

NCT04068753

NCT06365970

NCT05526989

NCT03748641

NCT06594679

NCT05187208

NCT03088059

NCT03601923

NCT04837209

NCT03307785

NCT03869190

NCT04577833

NCT04764084

NCT04679064

NCT05335993

NCT03891576

NCT04267939

NCT05238831

NCT03891615

NCT03840967

NCT03326193

NCT04926324

NCT03654833

NCT03768063

NCT04734665

NCT06747845

NCT04779151

NCT03368729

NCT04992013

NCT06412120

NCT03783949

NCT03945721

NCT04178460

NCT03983993

NCT01905592

NCT04194554

NCT04915755

NCT04221503

NCT06161493

NCT05666349

NCT06258018

NCT04508803

NCT05183984

NCT05385068

NCT05515575

NCT06433219

NCT03404960

NCT03903835

NCT02854436

NCT06141265

NCT05009082

NCT04313504

NCT04861181

NCT03025867

NCT04885413

NCT04080284

NCT05174455

NCT05162872

NCT04037254

NCT04235101

NCT06887933

NCT03586661

NCT02476552

NCT05130515

NCT05169437

NCT04409002

NCT05455424

NCT06180356

NCT04341181

NCT06212583

NCT03602859

NCT05198804

NCT03983226

NCT03895788

NCT03945084

NCT04716686

NCT02354586

NCT04715620

NCT02044120

NCT03830918

NCT04481113

NCT01847274

NCT06237205

NCT04284852

NCT02826512

NCT04681469

NCT04497844

NCT04395612

NCT04895046

NCT05961124

NCT04149145

NCT03308942

NCT05289648

NCT04392102

NCT04288687

NCT03329937

NCT03925350

NCT04655183

NCT04507841

NCT03425201

NCT05401214

NCT05232006

NCT06388733

NCT05442749

NCT04556071

NCT03221400

NCT03759587

NCT06964165

NCT03076203

NCT05412706

NCT06392841

NCT02657889

NCT04762901

NCT04991480

NCT03759600

Known as \[3S\]-3-\[4-\[7-(aminocarbonyl)-2H-indazol-2-yl\] phenyl\] piperidine \[tosylate monohydrate salt\] “Niraparib (\[3S\]-3-\[4-\[7-(aminocarbonyl)-2H-indazol-2-yl\] phenyl\] piperidine \[tosylate monohydrate salt\]) is an orally available, potent, and highly selective PARP1 and...” NCT05455424
Known as GSK3985771 “A Study of Niraparib (GSK3985771) Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy” NCT02655016
Known as JNJ-64091742 ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as MK-4827 TOSYLATE MONOHYDRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as MK4827 “Niraparib (MK4827) is an oral potent, selective PARP-1 and PARP-2 inhibitor that induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function.” PMID 23810788 Jun 2013
6

NCT01244009

NCT00749502

NCT01226901

NCT01110603

NCT01294735

NCT01227941

Known as NIR “This study evaluated the safety and dosing of the PARP1/2 inhibitor niraparib (NIR) with temozolomide (TMZ; arm 1) or irinotecan (IRN; arm 2) in patients with pretreated ES.” PMID 33289920 Dec 2020
Known as Nira “Participants will receive atezolizumab and Niraparib (Nira) until unacceptable toxicity or loss of clinical benefit, as determined by the investigator after an integrated...” NCT03869190
1

Niraparib plus Abiraterone Acetate (Nira/AA) combination” NCT05401214

Known as NIRAPARIB (MK-4827) ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as Niraparib (tosilate monohydrate) ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as Niraparib tosilate hydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as Niraparib tosylate ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as Niraparib tosylate component of akeega ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as NIRAPARIB TOSYLATE MONOHYDRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as Niraparib tosylate monohydrate component of akeega niraparib tosylate ChEMBL registry synonym — accepted as the source's own label CHEMBL1094636
Known as Zejula “The PRIMA study evaluated how well the drug niraparib, also known as Zejula, worked at delaying or preventing ovarian cancer from coming back (recurring) or getting worse...” PMID 38501262 Mar 2024
Known as ZL-2306 “A Randomized, Double-blind, Placebo-controlled, Multi-center, Phase 3 Study of ZL-2306 (Niraparib) as Maintenance Therapy Following First-line Platinum-based Chemotherapy in...” NCT03516084
6

“A Clinical Proof-of-concept Study Evaluating Efficacy and Safety of ZL-2306 (Niraparib) Combined With Brivanib or Toripalimab in Patients With Metastatic, Recurrent, and...” NCT04395612

“An Open-Label, Single-Arm, Phase I Clinical Trial to Evaluate the Safety and Tolerability of ZL-2306 (Niraparib) in Combination With Brivanib in Patients With Recurrent Ovarian Cancer” NCT03895788

“A Study of ZL-2306 (Niraparib) as Maintenance Treatment Following First-line Chemotherapy in Patients With Advanced Ovarian Cancer” NCT03709316

“Efficacy and Safety of ZL-2306 (Niraparib) in Ovarian Cancer Patient” NCT03705156

ZL-2306(Niraparib)” NCT04392102

NCT03551171

Action Inhibit “Niraparib is an orally active PARP inhibitor.” NCT01847274
Modality Small molecule “orally available small molecule PARP inhibitor” NCT03644342
Route Oral “Niraparib (MK4827) is an oral potent, selective PARP-1 and PARP-2 inhibitor” PMID 23810788 Jun 2013
Target PARP1 “This study evaluated the safety and dosing of the PARP1/2 inhibitor niraparib (NIR) with temozolomide (TMZ; arm 1) or irinotecan (IRN; arm 2) in patients with pretreated ES.” PMID 33289920 Dec 2020