Pharmacogenetics of Naltrexone for Stimulant Abuse

Summary

This investigation will be the first study assessing genetic modulation of naltrexone's NTX effects upon the abuse liability of a stimulant drug (methamphetamine). The study team will assess the ability of oral NTX to block the reinforcing and positive subjective effects of intranasal (IN) methamphetamine (30mg/70kg). This investigation could identify an important Gene x Pharmacological interaction, contributing to the personalization of stimulant abuse pharmacotherapy.

Timeline

Start

2016-09-15

Primary completion

2019-07-15

Completion

2020-07-30

Drugs

Indications