Drugs / Methamphetamine
Methamphetamine
also known as
Desoxyn · (s)-phenylmethylaminopropane · J6.362B · Metamfetamine · Metamfetamine hydrochloride · Metamphetamine · Metamphetamine hydrocloride · Metanfetamina · +8 more
Small molecule targets TAAR1 via activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | DESOXYN | — | 1943-12-31 | fda.gov ↗ |
Trials 16 · a red edge is where a trial was stopped
1942194319441945194619471948194919501951195219531954195519561957195819591960196119621963196419651966196719681969197019711972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029203020312032
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 05 trials | ||||||
| Phase 0 | NCT05379959 | May → Oct 2022 | substance abuse | University of Chicago | Completed | No outcome recorded |
| Phase 0 | NCT05003076 | Jul 2021 → Apr 2023 | — | University of Chicago | Completed | No outcome recorded |
| Phase 0 | NCT04642820 | Nov 2020 → Oct 2023 | substance abuse | University of Chicago | Completed | No outcome recorded |
| Phase 0 | NCT02058966 | Jun 2014 → Jun 2016 | methamphetamine dependence | Oregon Health and Science University | Completed | No outcome recorded |
| Phase 0 | NCT01967381 | Oct 2013 → Sep 2018 | methamphetamine dependence, substance abuse | University of Kentucky | Completed | No outcome recorded |
| Phase 15 trials | ||||||
| Phase 1 | NCT06746831 | Jul 2026 → Mar 2028 expected | substance-related disorder | University of Wisconsin, Madison | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT04614584 | May 2021 → May 2024 | methamphetamine dependence | San Francisco Department of Public Health | Completed | No outcome recorded |
| Phase 1 | NCT03106571 | Aug 2017 → Jul 2020 | methamphetamine dependence | University of California, Los Angeles | Terminated | No outcome recorded |
| Phase 1 | NCT03790618 | Jun 2016 → Aug 2018 | — | University of Chicago | Completed | No outcome recorded |
| Phase 1 | NCT01843205 | Apr 2013 → Mar 2017 | amphetamine abuse, methamphetamine dependence | University of Kentucky | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT03226223 | Sep 2016 → Jul 2019 | amphetamine abuse | New York State Psychiatric Institute | Completed | No outcome recorded |
| Phase 44 trials | ||||||
| Phase 4 | NCT07584369 | Jul 2026 → Jul 2029 expected | HIV infectious disease, substance-related disorder | University of California, San Francisco | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT03825536 | Jan 2021 → Jan 2023 | HIV infectious disease, methamphetamine dependence | University of California, San Francisco | Completed | No outcome recorded |
| Phase 4 | NCT03973489 | Aug 2019 → Mar 2023 | methamphetamine dependence | Oregon Health and Science University | Completed | No outcome recorded |
| Phase 4 | NCT01529892 | — | Amobarbital, deficient N-hydroxylation of | California Pacific Medical Center Research Institute | Withdrawn | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT02323048 | Jul → Nov 2014 | substance abuse | University of Chicago | Completed | No outcome recorded |
Also used as a comparator or background therapy in 3 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT06989853 Background | Aug 2025 → Feb 2029 expected | methamphetamine dependence | William Stoops | Recruiting | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT04178993 Comparator | Sep 2019 → May 2021 | methamphetamine dependence | Craig Rush | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT05783817 Comparator | Sep 2025 → Dec 2026 expected | obsessive-compulsive disorder | Carolyn Rodriguez | Recruiting | No outcome recorded |
Evidence & citations 21 cited values
Every value below carries the sentence it was read from. 20 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Methamphetamine | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06989853 ↗ |
| Known as | (s)-phenylmethylaminopropane | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Desoxyn | “The research proposed in this application will determine the initial efficacy, safety and tolerability of a novel drug combination, oxazepam (Serax®) and naltrexone (Revia®),...” NCT01967381 ↗1“Twenty milligrams of MA (Desoxyn; Lundbeck Inc) tablets will be crushed and placed in 10 ml of Ora-Sweet syrup.” NCT02323048 ↗ |
| Known as | J6.362B | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Metamfetamine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Metamfetamine hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Metamphetamine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Metamphetamine hydrocloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Metanfetamina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Methampex | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Methamphetamine hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | METHAMPHETAMINE HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Methamphetamine hydrochloride cii | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | Methylamfetamine hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | NSC-169505 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | NSC-25115 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201201 ↗ |
| Known as | S-(+)-methamphetamine | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06746831 ↗ |
| Action | Activate | “MA is a potent agonist at the TAAR1 receptor” NCT03973489 ↗ |
| Modality | Small molecule | — CHEMBL1201201 ↗ |
| Route | Oral | “a modest oral dose of 5 milligrams of methamphetamine” NCT01529892 ↗ |
| Target | TAAR1 | “MA is a potent agonist at the TAAR1 receptor” NCT03973489 ↗ |