drugset / Trial / NCT06746831

Methamphetamine Isomer Pharmacology in Humans

NCT06746831

RandomizedCrossoverDouble-blindTreatment

Summary

This study is being done to understand the metabolism and impairment profile of methamphetamine (meth). Meth exists as two chemical structures that are mirror images of each other: R-meth and S-meth. S-meth is a strong central nervous system stimulant and used to treat attention deficit disorder (ADD). R-meth is not a strong central nervous system stimulant and is available over-the-counter in nasal decongestant sprays.17 healthy participants will be enrolled for 3 study visits and on study for up to 12 weeks.

Timeline

Start
2026-07
Primary completion
2028-03
Completion
2028-03

Drugs

EvaluationDrugModalityDoseRoute
Subject Methamphetamine Small molecule 15 mg Intravenous
Subject R-(-)-methamphetamine Unknown 15 mg Intravenous
Subject racemic methamphetamine Unknown 15 mg Intravenous