Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia

Summary

Neuroapoptosis is induced by the administration of anesthetic agents to the young brain. Recent studies showed that the a2-adrenoceptor agonist, dexmedetomidine plays a trophic role during development and is neuroprotective in several settings of neuronal injury in animals. We hypothesized that neuroprotective effect of dexmedetomidine would be associated with evidence of brain injury detected by elevation of plasma concentration of glial fibrillary acid protein in children undergoing general anesthesia.

Timeline

Start

2017-09-01

Primary completion

2019-10-05

Completion

2019-10-05

Drugs

Indications

No indication recorded.