Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia

Summary

This is a prospective, randomized, single-blind trial evaluating prehospital patients experiencing moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5. Patients will be randomized to receive ketamine at or morphine by intravenous push.

Timeline

Start

2017-11-23

Primary completion

2022-11-26

Completion

2022-11-26

Outcome

Met primary endpoint

Stopped (Enrollment): “285 patients have recruited instead on 496 but we don't want to continue to prolonge the study. Analysis will be performed on the data we have.”

paper the use of intravenous ketamine compared with morphine showed noninferiority for pain reduction. PMID 38285446 ↗

Publications

• Le Cornec C, Le Pottier M, Broch H, Marguinaud Tixier A, Rousseau E, Laribi S, Janiere C, Brenckmann V, Guillerm A, Deciron F, Kabbaj A, Jenvrin J, Pere M, Montassier E. Ketamine Compared With Morphine for Out-of-Hospital Analgesia for Patients With Traumatic Pain: A Randomized Clinical Trial. JAMA Netw Open. 2024 Jan 2;7(1):e2352844. doi: 10.1001/jamanetworkopen.2023.52844.
• Le Cornec C, Lariby S, Brenckmann V, Hardouin JB, Ecoffey C, Le Pottier M, Fradin P, Broch H, Kabbaj A, Auffret Y, Deciron F, Longo C, Javaudin F, Le Bastard Q, Jenvrin J, Montassier E. Is intravenously administered, subdissociative-dose KETAmine non-inferior to MORPHine for prehospital analgesia (the KETAMORPH study): study protocol for a randomized controlled trial. Trials. 2018 May 2;19(1):260. doi: 10.1186/s13063-018-2634-3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	10 mg	Intravenous
Comparator	Morphine	Other / unclassified	2 mg	Intravenous
Comparator	Morphine	Other / unclassified	3 mg	Intravenous

Indications

No indication recorded.