drugset / Trial / NCT03236818

Goal Oriented Strategy to Preserve Ejection Fraction Trial

NCT03236818

Phase 4 Unknown 30 enrolled Amsterdam UMC, location VUmc
NaSingle-groupOpen-labelTreatment

Summary

In this prospective long term feasibility study we examine whether a goal oriented therapeutic strategy that is able to preserve right ventricular function will result in improved clinical outcome in patients with pulmonary arterial hypertension. We hypothesize that right ventricular function can only be preserved when early and aggressive medical combination therapy not only reduces pulmonary vascular resistance but also pulmonary pressures.

Timeline

Start
2013-05
Primary completion
2017-09
Completion
2017-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Bosentan Other / unclassified
Subject Macitentan Other / unclassified
Subject Sildenafil Unknown
Subject Tadalafil Small molecule