drugset / Trial / NCT03249558
Effect of Combined Morphine and Duloxetine on Chronic Pain
RandomizedParallel-groupTriple-blindOther
Summary
A double-blind, randomized, and placebo-controlled clinical study examining whether duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), could enhance opioid analgesia and reduce overall opioid use. Positive outcomes will help improve the overall effectiveness of clinical opioid therapy and reduce unnecessary opioid dose escalation.
Timeline
- Start
- 2018-03-12
- Primary completion
- 2022-04-05
- Completion
- 2022-04-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Duloxetine | Small molecule | 60 mg | — |
| Comparator | Morphine | Other / unclassified | 60 mg | — |