Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy

Summary

The goal of this study is to evaluate the effectiveness of different formulations of bupivacaine infiltrated into the transversus abdominis plane (TAP) on post-operative pain management after open abdominal hysterectomy.

Timeline

Start

2017-03-13

Primary completion

2019-01-30

Completion

2019-01-30

Outcome

Missed primary endpoint

paper and 51 [24-84] min in group mixture (P = 0.20). PMID 33432496 ↗

paper 203 [153-283] mg in group liposomal, and 202 [116-325] mg in group mixture (P = 0.92). PMID 33432496 ↗

paper mixture of liposomal bupivacaine with plain bupivacaine for TAP block did not improve analgesia compared with either liposomal bupivacaine or plain bupivacaine PMID 33432496 ↗

Publications

• Fidkowski CW, Choksi N, Alsaden MR. A randomized-controlled trial comparing liposomal bupivacaine, plain bupivacaine, and the mixture of liposomal bupivacaine and plain bupivacaine in transversus abdominus plane block for postoperative analgesia for open abdominal hysterectomies. Can J Anaesth. 2021 Jun;68(6):773-781. doi: 10.1007/s12630-020-01911-1. Epub 2021 Jan 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	0.25 %	Other
Subject	Bupivacaine	Other / unclassified	20 ml	Other
Subject	Bupivacaine	Other / unclassified	40 ml	Other
Subject	Bupivacaine	Other / unclassified	60 ml	Other

Indications

No indication recorded.