A Study to Assess the Effect of Plazomicin on the Pharmacokinetics of Metformin

Phase 1 Completed 16 enrolled Achaogen, Inc.

RandomizedCrossoverOpen-labelTreatment

Summary

This is a single-center, Phase 1, open label, randomized, two-sequence, two-period, crossover study to evaluate the drug-drug interaction potential between plazomicin and metformin in healthy subjects.

Timeline

Start: 2017-08-31
Primary completion: 2017-10-07
Completion: 2017-10-07

Publications

Choi T, Komirenko AS, Riddle V, Kim A, Dhuria SV. No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects. Clin Pharmacol Drug Dev. 2019 Aug;8(6):818-826. doi: 10.1002/cpdd.648. Epub 2019 Jan 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Metformin	Small molecule	850 mg	Oral
Subject	plazomicin	Small molecule	15 mg/kg	Intravenous

Indications

No indication recorded.