UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study

Summary

This study will be a single-site, controlled, unblinded study at the University of Wisconsin to examine changes in the electroencephalogram during anesthesia and waking.

Timeline

Start

2017-08-10

Primary completion

2020-03-12

Completion

2020-03-12

Outcome

Missed primary endpoint

registry analysis (superiority test); Propofol; p = 0.174; Slope 0.166; Mixed Models Analysis; note: Statistical significance defined by p < 0.05. NCT03284307 ↗

Publications

• Wehrman JJ, Casey C, Redinbaugh MJ, Muller E, Munn B, Payne T, Tanabe S, Mohanta S, Filbey W, Raz A, Banks MI, Pearce RA, Shine JM, Saalmann YB, Sanders RD. Thalamic contributions to predictive coding and disconnected consciousness in human volunteers. Br J Anaesth. 2026 Feb;136(2):573-583. doi: 10.1016/j.bja.2025.10.038. Epub 2025 Nov 27.
• Casey CP, Tanabe S, Farahbakhsh ZZ, Parker M, Bo A, White M, Ballweg T, Mcintosh A, Filbey W, Banks MI, Saalmann YB, Pearce RA, Sanders RD. Evaluation of putative signatures of consciousness using specific definitions of responsiveness, connectedness, and consciousness. Br J Anaesth. 2024 Feb;132(2):300-311. doi: 10.1016/j.bja.2023.09.031. Epub 2023 Oct 31.
• Wehrman JJ, Casey C, Tanabe S, Mohanta S, Filbey W, Weber L, Banks MI, Pearce RA, Saalmann Y, Sanders RD. Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection. Br J Anaesth. 2023 Oct;131(4):705-714. doi: 10.1016/j.bja.2023.06.044. Epub 2023 Aug 3.
• Casey CP, Tanabe S, Farahbakhsh Z, Parker M, Bo A, White M, Ballweg T, Mcintosh A, Filbey W, Saalmann Y, Pearce RA, Sanders RD. Distinct EEG signatures differentiate unconsciousness and disconnection during anaesthesia and sleep. Br J Anaesth. 2022 Jun;128(6):1006-1018. doi: 10.1016/j.bja.2022.01.010. Epub 2022 Feb 9.

Drugs

Indications

No indication recorded.