drugset / Trial / NCT03285165
Cerebral Vascular Effects of Dexmedetomidine Versus Propofol Sedation in Intubated Mechanically Ventilated ICU Patients
RandomizedParallel-groupDouble-blindTreatment
Summary
Serial transcranial Doppler (TCD) exams in healthy volunteers and in animal models showed a strong linear relationship between middle cerebral artery (MCA) flow velocity (FV) and dexmedetomidine infusion. The concomitant elevation of pulsatility index (PI) indicates vasoconstriction of the cerebral vasculature as the most profound underlying mechanism.
Timeline
- Start
- 2017-09-14
- Primary completion
- 2021-09-16
- Completion
- 2021-09-16
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.2 ug/kg | — |
| Comparator | Dexmedetomidine | Other / unclassified | 0.7 ug/kg | — |
| Comparator | Propofol | Small molecule | 10 ug/kg | — |
| Comparator | Propofol | Small molecule | 70 ug/kg | — |
Indications
No indication recorded.