ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension

Phase 2 Completed 223 enrolled University of Alabama at Birmingham AdventHealth Translational Research Institute · collab University of Colorado, Denver · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension when combined with physical exercise.

Timeline

Start: 2018-05-29
Primary completion: 2024-09-19
Completion: 2024-09-19

Publications

Harper SA, Baptista LC, Roberts LM, Wherry SJ, Boxer RS, Hildreth KL, Seay RS, Allman PH, Carter CS, Aban I, Kohrt WM, Buford TW. Angiotensin Converting Enzyme Inhibitors Combined with Exercise for Hypertensive Seniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial. Front Med (Lausanne). 2020 Jan 22;6:327. doi: 10.3389/fmed.2019.00327. eCollection 2019.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Hydrochlorothiazide	Unknown	25 mg	—
Comparator	Losartan	Other / unclassified	100 mg	—
Comparator	Perindopril	Small molecule	8 mg	—

ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension

Summary

Timeline

Publications

Drugs

Indications