Sedative-Anxiolytic Effects on Simulated Driving Performance

Phase 4 Completed 15 enrolled Marion Coe National Institute on Drug Abuse (NIDA) · collab

NaSingle-groupOpen-labelOther

Summary

This study evaluates the effect of anxiety drugs taken at night on the ability to drive a car the next day. Participants will receive alprazolam, placebo, or zolpidem at night before bed or in the morning before using a driving simulator to assess impairment.

Timeline

Start: 2017-09-15
Primary completion: 2018-10-25
Completion: 2018-10-25

Publications

Roszkowski SC, Babalonis S, Coe MA, Nuzzo PA, Lofwall MR, Fanucchi LC, Walsh SL. Residual next-day effects of alprazolam on psychomotor performance and simulated driving in healthy normal adults. Exp Clin Psychopharmacol. 2025 Apr;33(2):178-188. doi: 10.1037/pha0000746. Epub 2024 Nov 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Alprazolam	Small molecule	0.5 mg	—
Subject	Alprazolam	Small molecule	1 mg	—
Subject	Alprazolam	Small molecule	2 mg	—
Subject	Zolpidem	Small molecule	10 mg	—

Indications

No indication recorded.