drugset / Trial / NCT03319537
Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma
Phase 1/2
Terminated
9 enrolled
Memorial Sloan Kettering Cancer Center
M.D. Anderson Cancer Center · collab
Non-randomizedSequentialOpen-labelTreatment
Summary
The purpose of this study is to test any good and bad effects of activity pevonedistat taken alone, and also to test the safety of pevonedistat in combination with standard chemotherapy, pemetrexed/cisplatin.
Timeline
- Start
- 2017-10-05
- Primary completion
- 2023-06-05
- Completion
- 2023-06-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Pevonedistat | Small molecule | 50 mg/m2 | Intravenous |
| Background | Cisplatin | Other / unclassified | 75 mg/m2 | — |
| Background | Pemetrexed | Small molecule | 500 mg/m2 | — |