drugset / Trial / NCT03324412
Efficacy and Safety of TwHF and MTX in Patients With Rheumatoid Arthritis
RandomizedParallel-groupDouble-blindTreatment
Summary
Rheumatoid Arthritis (RA) is an autoimmune disease that results in a chronic inflammatory disorder that may affect many synovial joints, and may cause serious disability. It has been confirmed that Tripterygium Wilfordii has effects of anti-inflammatory, immunosuppressive and cartilage protection. This is a multicenter ,double Blind, randomized study to evaluated the efficacy and safety of Tripterygium Wilfordii in treating of patients with rheumatoid arthritis (RA) and establish a prediction model for Tripterygium Wilfordii response of rheumatoid arthritis (RA).
Timeline
- Start
- 2017-10-28
- Primary completion
- 2019-05-31
- Completion
- 2019-09-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Tripterygium wilfordii Hook F | Traditional medicine (herbal / TCM) | 20 mg | Oral |
| Comparator | Methotrexate | Small molecule | 10 mg | Oral |
| Comparator | Methotrexate | Small molecule | 15 mg | Oral |