The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users

Phase 1 Completed 48 enrolled University of Colorado, Denver Merck Sharp & Dohme LLC · collab

NaSingle-groupOpen-labelTreatment

Summary

A prospective, non-inferiority study to evaluate the pharmacokinetic effect of topiramate on serum Etonogestrel (ENG) levels in contraceptive implant users.

Timeline

Start: 2018-03-15
Primary completion: 2021-04-22
Completion: 2021-04-22

Publications

Lazorwitz A, Pena M, Sheeder J, Teal S. Effect of Topiramate on Serum Etonogestrel Concentrations Among Contraceptive Implant Users. Obstet Gynecol. 2022 Apr 1;139(4):579-587. doi: 10.1097/AOG.0000000000004697. Epub 2022 Mar 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Topiramate	Small molecule	200 mg	Oral

The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users

Summary

Timeline

Publications

Drugs

Indications