Estrogen and the Urogenital Microbiome in GSM

Phase 4 Completed 40 enrolled Oregon Health and Science University

RandomizedParallel-groupSingle-blindBasic science

Summary

This is a study of how local estrogen treatment affects the microbiome of the vagina and bladder in postmenopausal women experiencing symptoms as part of "Genitourinary Syndrome of Menopause." The goal is to understand more about the underlying microbial changes occurring in menopause and whether these are reversible with estrogen.

Timeline

Start: 2018-02-01
Primary completion: 2019-08-23
Completion: 2019-08-23

Publications

Lillemon JN, Karstens L, Nardos R, Garg B, Boniface ER, Gregory WT. The Impact of Local Estrogen on the Urogenital Microbiome in Genitourinary Syndrome of Menopause: A Randomized-Controlled Trial. Female Pelvic Med Reconstr Surg. 2022 Jun 1;28(6):e157-e162. doi: 10.1097/SPV.0000000000001170. Epub 2022 Apr 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Estradiol	Other / unclassified	2 mg	Other

Indications

No indication recorded.