drugset / Trial / NCT03346226
How Different Sedatives Affect Hip Fracture Patient's Postoperative Delirium
Phase 4
Unknown
1000 enrolled
Shanghai Zhongshan Hospital
Beijing Jishuitan Hospital · collabFirst Affiliated Hospital of Guangxi Medical University · collabFoshan Hospital of Traditional Chinese Medicine · collabQianfoshan Hospital · collabSecond Hospital of Shanxi Medical University · collabShanghai 6th People's Hospital · collabShanghai Changzheng Hospital · collabTang-Du Hospital · collabThe First Affiliated Hospital of Nanchang University · collabThe First Affiliated Hospital of Soochow University · collabThe Fuzhou No 2 Hospital · collabThe Second Affiliated Hospital of Harbin Medical University · collab
RandomizedParallel-groupSingle-blindPrevention
Summary
the hypothesis is that Dexmedetomidine seems to decrease incidence of post-operative delirium . one possible mechanism is that Dex have a minor influence on cognition, since it has no effect on GABA receptor，another is that Dex could induce a sleep similar to natural sleep, thereby decreasing sleep deprivation and circadian rhythm disorder in post-operative patients. In this study , investigators devise the two different sedatives(Dexmedetomidine and Propofol)'influence on postoperative delirium in hip fracture elderly participants under spinal anesthesia
Timeline
- Start
- 2018-01-01
- Primary completion
- 2018-12-30
- Completion
- 2019-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 0.5 ug/kg | — |
| Comparator | Propofol | Small molecule | 2 mg/kg | — |
| Comparator | Propofol | Small molecule | 10 mg/kg | — |