drugset / Trial / NCT03349775
Cardiometabolic Disease and Pulmonary Hypertension
Phase 0
Terminated
21 enrolled
Massachusetts General Hospital
National Heart, Lung, and Blood Institute (NHLBI) · collab
RandomizedParallel-groupQuadruple-blindOther
Summary
This study will investigate if metformin can help people with obesity and high pressures inside their lung blood vessels. Metformin is approved by the U.S. Food and Drug Administration (FDA) to treat diabetes, but metformin is not approved by the FDA to treat pulmonary hypertension. This study will examine whether Metformin will improve the high pressure inside lung blood vessels in people who are obese. The study will help understand the effect of metformin on pressures inside lung blood vessels.
Timeline
- Start
- 2017-11-27
- Primary completion
- 2020-12-22
- Completion
- 2020-12-22
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Metformin | Small molecule | 1 g | Oral |