drugset / Trial / NCT03361735

Radium Ra 223 Dichloride, Hormone Therapy and Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Prostate Cancer

NCT03361735

Phase 2 Active not recruiting 25 enrolled City of Hope Medical Center
NaSingle-groupOpen-labelTreatment

Summary

This phase 2 trial studies radium Ra 223 dichloride, hormone therapy and stereotactic body radiation in treating patients with prostate cancer that has spread to other places in the body. Radium Ra 223 dichloride contains a radioactive substance that collects in the bone and gives off radiation that may kill cancer cells. Hormone therapy using leuprolide acetate or goserelin acetate may fight prostate cancer by lowering the amount of testosterone the body makes. Stereotactic body radiation therapy is a specialized radiation therapy that sends x-rays directly to the tumor using smaller doses over several days and may cause less damage to normal tissue. Giving radium Ra 223 dichloride, hormone therapy and stereotactic body radiation may work better at treating prostate cancer.

Timeline

Start
2018-08-29
Primary completion
2024-03-21
Completion
2027-01-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Degarelix Other / unclassified Subcutaneous
Subject Goserelin Other / unclassified Subcutaneous
Subject Leuprolide Other / unclassified Intramuscular