Drugs / Goserelin
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Goserelin

Other / unclassified

Developed for
prostate cancer · breast cancer · female breast carcinoma · prostate adenocarcinoma · Her2-receptor negative breast cancer · estrogen-receptor positive breast cancer · infertility disorder · ovarian dysfunction
+31 more · endometriosis · HER2 positive breast carcinoma · hormone receptor-positive breast cancer · triple-negative breast carcinoma · breast neoplasm · invasive breast carcinoma · leiomyoma · metastatic prostate carcinoma · premature menopause · primary ovarian failure · prostate carcinoma · salivary gland carcinoma · azoospermia · breast mucinous carcinoma · bulbospinal muscular atrophy · cancer · endometrial cancer · endometrial endometrioid adenocarcinoma · fallopian tube carcinoma · inflammatory breast carcinoma · invasive tubular breast carcinoma · Kennedy disease · male breast carcinoma · NAFLD1 · ovarian carcinoma · peritoneal carcinoma · prostate disorder · prostate neoplasm · salivary gland cancer · submucous uterine fibroid · uterine disorder
Investigated by
National Cancer Institute (NCI) · AstraZeneca · Radiation Therapy Oncology Group · Fudan University · SWOG Cancer Research Network · Eastern Cooperative Oncology Group
+150 more · European Organisation for Research and Treatment of Cancer - EORTC · NRG Oncology · Cancer and Leukemia Group B · M.D. Anderson Cancer Center · Pfizer · Alliance for Clinical Trials in Oncology · Mayo Clinic · Memorial Sloan Kettering Cancer Center · Peking Union Medical College Hospital · The First Affiliated Hospital of Zhengzhou University · The First People's Hospital of Yunnan · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Zhejiang University · Bayer · Beth Israel Deaconess Medical Center · City of Hope Medical Center · Dana-Farber Cancer Institute · Eurofarma Laboratorios S.A. · GBG Forschungs GmbH · Genentech, Inc. · Genomic Health®, Inc. · Institute of Cancer Research, United Kingdom · Korean Breast Cancer Study Group · NCIC Clinical Trials Group · NYU Langone Health · Novartis Pharmaceuticals · Peking University People's Hospital · Peptigroupe Inc. · Proton Collaborative Group · Qilu Hospital of Shandong University · RenJi Hospital · Rigshospitalet, Denmark · Roche Pharma AG · Scottish Cancer Therapy Network · Shengjing Hospital · Tampere University · The First Affiliated Hospital of Xiamen University · Tongji Hospital · University of Sao Paulo · University of Washington · Washington University School of Medicine · Wuhan TongJi Hospital · Zhejiang Cancer Hospital · 424 General Military Hospital · AbbVie · Abdenour Nabid · Anglo Celtic Cooperative Oncology Group · Aristotle University Of Thessaloniki · Artera · Asan Medical Center · Assiut University · Astellas Pharma Inc · Atossa Therapeutics, Inc. · Austrian Breast & Colorectal Cancer Study Group · Bayer Yakuhin, Ltd. · Beijing Chao Yang Hospital · Benaroya Research Institute · Beni-Suef University · Bradley Nindl · Breast Cancer Research Foundation · Brigham and Women's Hospital · Bristol-Myers Squibb · CMX Research · Canadian Cancer Trials Group · Cancer Research Campaign Clinical Trials Centre · Cancer Research UK · Cankado GmbH · Celgene Corporation · Chinese PLA General Hospital · Chugai Pharmaceutical · Debiopharm International SA · ETOP IBCSG Partners Foundation · Eisai Inc. · Eli Lilly and Company · all 156 on the full record

Regulatory milestones approvals, filings & regulatory actions · 5 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (4) US (FDA) ZOLADEX 1993-02-02 – 1998-07-27 fda.gov
Approved US (FDA) ZOLADEX 1989-12-29 fda.gov

Trials 156 · started per year

today
US approved 1989
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198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT07516704 Apr 2026 → Dec 2027 expected prostate cancer Zhongda Hospital Not yet recruiting No outcome recorded
Phase 0 NCT03511196 Sep 2018 → Jun 2022 overdue prostate adenocarcinoma H. Lee Moffitt Cancer Center and Research Institute Active not recruiting No outcome recorded
Phase 0 NCT04060043 Feb → Dec 2017 prostate cancer CMX Research Completed No outcome recorded
Phase 14 trials
Phase 1 NCT07310420 Jun → Nov 2026 expected breast cancer TerSera Therapeutics LLC Recruiting No outcome recorded
Phase 1 NCT04428684 Oct 2018 → Apr 2020 uterine disorder Peptigroupe Inc. Completed No outcome recorded
Phase 1 NCT02023463 Apr 2014 → Jul 2017 overdue prostate adenocarcinoma Thomas Jefferson University Active not recruiting No outcome recorded
Phase 1 NCT02911350 May 2000 → Dec 2016 prostate cancer NYU Langone Health Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT04215003 Jan 2020 → Dec 2024 breast cancer Fudan University Unknown No outcome recorded
Phase 1/2 NCT00669162 Aug 2012 → Aug 2016 prostate cancer University of Kansas Medical Center Completed No outcome recorded
Phase 1/2 NCT00653757 Mar 2002 → Dec 2006 prostate cancer Mayo Clinic Completed No outcome recorded
Phase 267 trials
Phase 2 NCT07610733 Jun 2026 → Sep 2027 expected breast cancer Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT07460752 May 2026 → Sep 2028 expected female breast carcinoma, hormone receptor-positive breast cancer Mayo Clinic Recruiting No outcome recorded
Phase 2 NCT07287098 May 2026 → Jan 2029 expected breast neoplasm Eli Lilly and Company Recruiting No outcome recorded
Phase 2 NCT07450599 Apr 2026 → Jun 2028 expected Bayer Recruiting No outcome recorded
Phase 2 NCT07158021 Jan 2026 → Jan 2028 expected female breast carcinoma, invasive breast carcinoma University of Michigan Rogel Cancer Center Recruiting No outcome recorded
Phase 2 NCT07313241 Nov 2025 → Nov 2030 expected prostate cancer University of Texas Southwestern Medical Center Recruiting No outcome recorded
Phase 2 NCT07179939 Sep 2025 → Dec 2030 expected HER2 positive breast carcinoma Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT06953882 Jul 2025 → Sep 2030 expected Her2-receptor negative breast cancer Yale University Recruiting No outcome recorded
Phase 2 NCT06772441 Nov 2024 → Oct 2026 expected prostate cancer German Oncology Center, Cyprus Recruiting No outcome recorded
Phase 2 NCT06225284 Aug 2024 → Dec 2026 expected triple-negative breast carcinoma National Taiwan University Hospital Recruiting No outcome recorded
Phase 2/35 trials
Phase 2/3 NCT06009627 Apr 2023 → Mar 2025 breast cancer Tianjin Medical University Cancer Institute and Hospital Completed No outcome recorded
Phase 2/3 NCT05253066 Feb → Jul 2022 breast neoplasm Shengjing Hospital Unknown No outcome recorded
Phase 2/3 NCT03373708 Dec 2017 → Dec 2019 breast cancer Zhiyong Yu Unknown No outcome recorded
Phase 2/3 NCT02221999 Sep 2013 → Jan 2019 overdue breast mucinous carcinoma, inflammatory breast carcinoma, invasive tubular breast carcinoma RenJi Hospital Active not recruiting No outcome recorded
Phase 2/3 NCT01603420 Jul 2012 → May 2014 prostate cancer Proton Collaborative Group Terminated No outcome recorded
Phase 347 trials
Phase 3 NCT03936933 Oct 2020 → Sep 2024 breast cancer Eurofarma Laboratorios S.A. Terminated No outcome recorded
Phase 3 NCT03936218 Sep 2020 → Nov 2023 prostate cancer Eurofarma Laboratorios S.A. Completed No outcome recorded
Phase 3 NCT03658213 Mar 2020 → Nov 2021 breast cancer AstraZeneca Withdrawn No outcome recorded
Phase 3 NCT03054168 Dec 2016 → Nov 2018 muscular atrophy University of Nottingham Unknown No outcome recorded
Phase 3 NCT02532400 Mar 2016 → Mar 2019 breast cancer Ruijin Hospital Terminated No outcome recorded
Phase 3 NCT02518191 Sep 2015 → Jan 2021 female breast carcinoma Xiangyun Zong Completed No outcome recorded
Phase 3 NCT02344472 Sep 2015 → Jan 2025 breast cancer University of Ulm Unknown No outcome recorded
Phase 3 NCT02535221 Jul 2015 → Jun 2026 overdue breast cancer Peking University Recruiting No outcome recorded
Phase 3 NCT02483767 Jun 2015 → Nov 2016 breast cancer Peking Union Medical College Hospital Completed No outcome recorded
Phase 3 NCT02132390 May 2014 → May 2024 breast cancer, chemotherapy-induced toxicity Peking Union Medical College Hospital Unknown No outcome recorded
Phase 412 trials
Phase 4 NCT06523530 Nov 2024 → Apr 2027 expected NAFLD1, endometriosis Aristotle University Of Thessaloniki Recruiting No outcome recorded
Phase 4 NCT06455969 Jul 2024 → Aug 2026 overdue hypogonadism, musculoskeletal system disorder Bradley Nindl Recruiting No outcome recorded
Phase 4 NCT05333328 Feb 2023 → Jan 2031 expected Her2-receptor negative breast cancer, estrogen-receptor positive breast cancer Gangnam Severance Hospital Recruiting No outcome recorded
Phase 4 NCT03971110 Jan 2021 → Nov 2022 prostate cancer AstraZeneca Terminated No outcome recorded
Phase 4 NCT04248621 Jan 2020 → Apr 2022 prostate neoplasm Wonju Severance Christian Hospital Unknown No outcome recorded
Phase 4 NCT01738724 Jan 2012 → Dec 2016 leiomyoma University of Sao Paulo Terminated No outcome recorded
Phase 4 NCT00851461 Apr 2008 → Nov 2011 Kennedy disease, bulbospinal muscular atrophy Ramathibodi Hospital Completed No outcome recorded
Phase 4 NCT00654524 Mar 2008 → Dec 2009 endometriosis Zhejiang University Unknown No outcome recorded
Phase 4 NCT00286351 Jan 2005 → ? endometriosis Rigshospitalet, Denmark Completed No outcome recorded
Phase 4 NCT00293696 Oct 2004 → Nov 2006 prostate cancer Tampere University Completed No outcome recorded
Phase not applicable15 trials
NCT07552493 May 2026 → May 2027 expected disease related to hematopoietic stem cell transplant, ovarian dysfunction Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Not yet recruiting No outcome recorded
NCT07552506 May 2026 → May 2027 expected aplastic anemia, disease related to hematopoietic stem cell transplant, ovarian dysfunction Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Not yet recruiting No outcome recorded
NCT07552480 May 2026 → May 2027 expected disease related to hematopoietic stem cell transplant, hematopoietic and lymphoid system neoplasm, ovarian dysfunction Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Not yet recruiting No outcome recorded
NCT07172685 Jul 2025 → Jun 2026 overdue prostate cancer Qilu Hospital of Shandong University Recruiting No outcome recorded
NCT06636591 Dec 2024 → Jan 2026 Her2-receptor negative breast cancer, female breast carcinoma Fudan University Completed No outcome recorded
NCT05898321 Jun 2023 → Dec 2024 submucous uterine fibroid Women's Hospital School Of Medicine Zhejiang University Unknown No outcome recorded
NCT04220398 Jan 2020 → Dec 2022 chemotherapy-induced toxicity, prostate carcinoma RenJi Hospital Unknown No outcome recorded
NCT03440879 Sep 2018 → Mar 2023 prostate cancer Norwegian School of Sport Sciences Terminated No outcome recorded
NCT02932761 Nov 2016 → Jan 2018 Xipeng Wang Unknown No outcome recorded
NCT05945407 Aug 2016 → Dec 2023 overdue endometrial cancer, endometrial endometrioid adenocarcinoma Peking University People's Hospital Recruiting No outcome recorded
Also used as a comparator or background therapy in 192 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT07389174 Background Feb 2026 → Jan 2027 expected prostate adenocarcinoma Shanghai Changzheng Hospital Not yet recruiting No outcome recorded
Phase 0 NCT07389187 Background Feb → Dec 2026 expected castration-resistant prostate carcinoma Shanghai Changzheng Hospital Not yet recruiting No outcome recorded
Phase 120 trials
Phase 1 NCT05617885 Background Aug 2023 → Jul 2025 metastatic prostate carcinoma Praful Ravi, MB BCHir, MRCP Completed No outcome recorded
Phase 1 NCT05856630 Comparator May → Dec 2023 prostate cancer Luye Pharma Group Ltd. Unknown No outcome recorded
Phase 1 NCT05755581 Comparator Apr 2023 → Apr 2025 breast cancer Sohag University Unknown No outcome recorded
Phase 1 NCT05140512 Comparator Feb → Sep 2021 prostate cancer Luye Pharma Group Ltd. Completed No outcome recorded
Phase 1 NCT03450109 Comparator Dec 2017 → Oct 2018 prostate cancer Luye Pharma Group Ltd. Completed No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT07596212 Background Jul 2026 → Jul 2028 expected hormone receptor-positive breast cancer, hypoactive sexual desire disorder University of Illinois at Chicago Not yet recruiting No outcome recorded
Phase 1/2 NCT05003752 Background Aug 2021 → Dec 2022 overdue prostate adenocarcinoma, radiation-induced disorder German Oncology Center, Cyprus Active not recruiting No outcome recorded
Phase 1/2 NCT03587285 Background Sep 2018 → Jul 2021 prostate neoplasm Guangzhou University of Traditional Chinese Medicine Unknown No outcome recorded
Phase 1/2 NCT01163084 Background Jul 2010 → Jun 2012 prostate adenocarcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1/2 NCT00003394 Background Apr 1998 → Apr 2003 prostate cancer Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 287 trials
Phase 2 NCT07142551 Background Mar 2026 → Jun 2030 expected castration-resistant prostate carcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 2 NCT07268794 Background Nov 2025 → Apr 2027 expected metastatic prostate carcinoma, prostate adenocarcinoma Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT06922318 Background Aug 2025 → Aug 2031 expected castration-resistant prostate carcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 2 NCT06832774 Background Aug 2025 → Dec 2027 expected metastatic prostate carcinoma Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Recruiting No outcome recorded
Phase 2 NCT06528210 Background Apr 2025 → Jun 2026 prostate adenocarcinoma OHSU Knight Cancer Institute Withdrawn No outcome recorded
Phase 2/35 trials
Phase 2/3 NCT06282588 Background Dec 2023 → Jul 2030 expected prostate cancer Cancer Research Antwerp Recruiting No outcome recorded
Phase 2/3 NCT04787744 Background Jul 2021 → Sep 2026 expected metastatic prostate carcinoma VA Office of Research and Development Recruiting No outcome recorded
Phase 2/3 NCT03070886 Background Apr 2017 → Oct 2025 prostate adenocarcinoma NRG Oncology Completed No outcome recorded
Phase 2/3 NCT02685397 Background Oct 2016 → Apr 2027 expected castration-resistant prostate carcinoma Sir Mortimer B. Davis - Jewish General Hospital Active not recruiting No outcome recorded
Phase 2/3 NCT01218581 Comparator Dec 2005 → Jan 2010 Mansoura University Completed No outcome recorded
Phase 356 trials
Phase 3 NCT07477626 Background Mar 2026 → Dec 2033 expected metastatic malignant neoplasm in the lymph nodes, prostate cancer Sun Yat-sen University Recruiting No outcome recorded
Phase 3 NCT05827081 Background Feb 2024 → Sep 2029 expected female breast carcinoma Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT06447623 Background Feb 2024 → Feb 2027 expected hormone receptor-positive breast cancer Fudan University Recruiting No outcome recorded
Phase 3 NCT05879926 Comparator Oct 2023 → Jan 2032 expected breast cancer NRG Oncology Recruiting No outcome recorded
Phase 3 NCT05891093 Background Jun 2023 → May 2028 expected breast cancer Fudan University Recruiting No outcome recorded
Phase 48 trials
Phase 4 NCT05700903 Comparator Sep 2023 → Jul 2025 dysautonomia, hypertensive disorder, kidney disorder, prostate cancer University of Colorado, Denver Completed No outcome recorded
Phase 4 NCT05161195 Background Jul 2022 → Jun 2030 expected metastatic malignant neoplasm Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase 4 NCT05013242 Comparator Dec 2020 → Nov 2021 endometriosis Mansoura University Unknown No outcome recorded
Phase 4 NCT03591549 Background Aug 2018 → Aug 2021 breast cancer Assiut University Unknown No outcome recorded
Phase 4 NCT01673984 Comparator Aug 2012 → Feb 2014 prostate cancer Ipsen Terminated No outcome recorded
Phase not applicable9 trials
NCT07483658 Background May 2026 → Dec 2029 expected prostate cancer CHU de Quebec-Universite Laval Recruiting No outcome recorded
NCT05628363 Background Jan 2023 → Oct 2025 overdue prostate cancer Washington University School of Medicine Active not recruiting No outcome recorded
NCT04894188 Background Jan 2022 → Jul 2024 overdue prostate cancer National Taiwan University Hospital Recruiting No outcome recorded
NCT02594072 Background Apr 2016 → Dec 2024 prostate cancer University of British Columbia Unknown No outcome recorded
NCT02454543 Background May 2015 → Dec 2019 overdue prostate cancer Martini-Klinik am UKE GmbH Active not recruiting No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 349 sources stand behind the page.

FieldValueCited text
Known as Goserelin “All patients receive neoadjuvant androgen-deprivation therapy comprising bicalutamide orally (PO) once daily or flutamide PO thrice daily for 4-6 months, and luteinizing...” NCT01368588
241

“METHODS: Forty women were assessed for eligibility at gynaecology clinics in the region, of whom thirty premenopausal women scheduled for hysterectomy due to symptomatic...” PMID 24608161 Mar 2014

“Drug name: Zoladex Generic Name: Gonadotropin-releasing hormone analogue; Goserelin Proprietary Name: N/A Formulation: Solution for injection Dose: 3.6mg Frequency: Single...” NCT03054168

“This regimen consists of Androgen Deprivation Therapy (ADT) (e.g., Goserelin, Leuprorelin, Triptorelin, or Degarelix) combined with an oral Androgen Receptor (AR) inhibitor...” NCT07389174

“Participants will be administered with LHRHa (example, leuprolide, goserelin, triptorelin acetate) as a 3-monthly depot preparation within 3 days after randomization and the...” NCT04557059

“Dosing of goserelin (dose and frequency of administration) will be consistent with the prescribing information and should only be adjusted if clinically indicated to achieve...” NCT02867020

“In patients randomized to receive GnRHa, 3.6 mg of goserelin or 3.75 mg of leuprorelin was injected subcutaneously once every 28 days from 1 to 2 weeks before the first cycle...” PMID 34967844 Feb 2022

“A Multi-centre, Single-arm, Prospective Study to Assess Efficacy and Safety of Neoadjuvant Hormone Therapy Using Zoladex (Goserelin) and Casodex (Bicalutamide) in Patients With...” NCT03971110

“LHRH analogue (either leuprolide or goserelin): Leuprolide is an intramuscular injection, and goserelin subcutaneous (under skin) of abdomen, given either 1 injection every 3...” NCT01088529

“Pre- and peri-menopausal women will be receiving Ovarian Function Suppression (OFS) by either leuprorelin subcutaneous 3.75 mg q28days or goserelin subcutaneous 3.6 mg q28days...” NCT03969121

“Ovarian function suppression can be achieved by choice of goserelin at a dose of 3.6 mg administered by means of subcutaneous injection every 28 days,bilateral oophorectomy,or...” NCT02440230

“Androgen blockade : 36 months of androgen blockade : bicalutamide 50 mg die for one month, goserelin 10.8 mg x 12 Q 3 months + radiation therapy : pelvis 44 grays , prostate 70...” NCT00223171

“The primary objective of the study is to demonstrate non-inferiority of a generic formulation of goserelin 3.6 mg as compared to Zoladex ® 3.6 mg on endometrial thinning prior...” NCT04428684

“The goserelin implant (Zoladex®) 3.6 mg is administered subcutaneously every 28 days into the anterior abdominal wall using a pre-filled syringe with a 16G needle (outer...” NCT06385847

“Phase II Clinical Study of Darsilide Combined With Exemestane+Goserelin Neoadjuvant Endocrine Therapy in HR Positive and HER2 Negative Premenopausal Breast Cancer Patients” NCT06009627

“Flutamide, FLUT, NSC-147834; Goserelin, Zoladex, ZDX, NSC-606864; with irradiation of the whole pelvis followed by a boost to the prostate using photons of at least 6 MV.” NCT00769548

“All patients will receive luteinizing hormone-releasing hormone (LHRH) agonist therapy (leuprolide or goserelin acetate) concurrent with Cabazitaxel, before surgery.” NCT01531205

“1-month GnRH (goserelin 3.6 mg depot or goserelin 3.6 mg implant or leuprolide 3.75 mg depot) +endocrine therapy (aromatase inhibitor/tamoxifen±CDK4/6 inhibition)” NCT07610733

Goserelin, a gonadotropin releasing hormone agonist (GnRHα) was used to suppress endogenous gonadotropin levels (gonadotropin reset) in the NOA patients” PMID 30243299 Sep 2018

“AHT group receives 9 cycle of LHRH-A (goserelin acetate 3.6 mg/4 weeks or leuprorelin acetate 3.75 mg/4 weeks) after Iodine I-125 implantation (TPPB).” NCT00664456

“Androgen suppression therapy using luteinizing hormone-releasing hormone (LHRH) agonists such as leuprolide, goserelin, buserelin, triptorelin.” NCT01603420

“Androgen deprivation therapy includes available GnRH agonists and antagonists, such as Triptorelin, Leuprolide, Goserelin and Degarelix.” NCT07477626

“The specific dosage is goserelin 3.6 mg, administered as a subcutaneous injection into the anterior abdominal wall once every 28 day” NCT07516704

“Hypodermic injection of Luteinizing Hormone-Releasing Hormone Analog every 4 weeks including goserelin, leuprolide, triptorelin ect.” NCT04992026

“LHRH agonist (such as leuprolide, goserelin, buserelin, or triptorelin) for 6 months, starting within 6 weeks after registration” NCT00528866

Goserelin: 3.6mg, d1, hypodermic injection , q28d\*7 plus exemestane: 25mg, po, qd\*24w, or anastrozole: 1mg, po, qd\*24w” NCT02532400

Goserelin (3.6mg) will be given subcutaneously (under the skin) on Day 1 of each cycle x 4 cycles. (Other Names: Zoladex)” NCT03573648

“gonadotropin-releasing hormone agonist ("Leuprorelin", "Goserelin" or "Triptorelin") 3.75mg/28d injection subcutaneously” NCT05945407

“luteinizing hormone-releasing hormone (LHRH) agonist (e.g., leuprolide acetate, goserelin, buserelin, or triptorelin)” NCT00288080

“ADT with Leuprolide, Goserelin, or Triptorelin, as GnRH agonist, every 4 weeks as outlined in study arm description.” NCT03511196

“Drugs, such as goserelin, leuprolide, flutamide, or bicalutamide, may stop the adrenal glands from making androgens.” NCT00103376

Goserelin (3.75mg, once every 4 weeks)+Docetaxel (75 mg/m2 on day 1 every 3 weeks)+Prednisone (5 mg, twice daily)” NCT03696186

“gonadotropin-releasing hormone analog (leuprolide, goserelin, or triptorelin as determined by treating physician)” NCT03279250

“Maintenance of ADT using GnRH agonist or antagonist (e.g., Goserelin, Leuprorelin, Triptorelin, or Degarelix).” NCT07389187

“Releasing hormone agonists (such as leuprolide, goserelin, buserelin, triptorelin) will be given for 4 months” NCT00004054

“LHRH agonist (antagonist) therapy consists of leuprolide, goserelin, buserelin, triptorelin, or degarelix.” NCT00936390

“GnRH agonist or antagonist (leuprolide, goserelin, degarelix) administered as per institutional standard.” NCT07313241

“GnRH analog Goserelin acetate 3.6 mg every 4 weeks with tamoxifen 20 mg daily for premenopausal patients” NCT05755581

“If the patient is premenopausal, leuprorelin 3.75mg or goserelin 3.6 mg will be injected every 28 days.” NCT04465097

“Options commonly include goserelin, leuprolide, or triptorelin given monthly or every-three-months.” NCT05879926

Goserelin, leuprolide, premenopausal patients only, selected at the discretion of the investigator.” NCT05983107

“Monthly or quarterly LHRH Agonist Depot injection (leuprolide or goserelin acetate) for one year.” NCT01076335

“Hormonal therapy with a luteinizing hormone-releasing hormone (LHRH) agonist (e.g., goserelin)” NCT07483658

“ADT is defined as a GnRH agonist/antagonist (leuprolide, goserelin, degarelix, or relugolix).” NCT05628363

“GnRHa (Goserelin 10.8 mg sustained-release implant, subcutaneous injection, every 3 months)” NCT07172685

“GNRH agonist (leuprolide, goserelin, triptorelin) or GNRH antagonist (relugolix, degarelix)” NCT06528210

Goserelin acetate implant for pre- or perimenopausal female and male participants only” NCT05085002

“Acceptable agents include goserelin or leuprolide; triptorelin is also acceptable.” NCT04931342

“Some participants will also get either goserelin or leuprorelin once every month.” NCT04711252

“Triptorelin 3,75 mg or Leuprolide 3,75 mg or goserelin 3,6 mg, as injectable.” NCT03944434

“gonadotropin-releasing hormone (GnRH) analogues (e.g. goserelin, leuprolide)” NCT02454543

“A stable regimen of goserelin 3.6 mg will be administered as a GnRH agonist.” NCT04325828

goserelin acetate: 10.8mg given SC every 3 months for a total of 6 months” NCT00776594

“Available drugs include triptorelin, goserelin, leuprolide, digareke ect.” NCT05406999

“* Goserelin (10.8 mg s.c. after randomisation and after three months) or” NCT01638247

Goserelin: 3.6 mg every 28 days, subcutaneous injection in the abdomen.” NCT06656624

“leuprolide and goserelin are gonadotropin-releasing hormone analogues” NCT00586898

“This includes leuprolide, goserelin, triptorelin, and degarelix.” NCT02972060

“10.8 mg depot for injection (equivalent to 10.8 mg goserelin)” NCT03658213

“Either goserelin acetate or leuprorelin Acetate is allowed.” NCT05333328

“switch to adjuvant anastrozole plus goserelin (ADD group)” PMID 30643455 Dec 2018

“* Goserelin: subcutaneous implant, 3.6 mg or 10.8 mg, or” NCT07553988

“Postmenopausal participants should use Goserelin.” NCT06447623

“Postmenopausal participants should use Goserelin.” NCT05949541

Goserelin 3.6 mg q28d or Leuprolide 11.25 mg q3m” NCT02221999

“leuprolide, goserelin, buserelin, or triptorelin” NCT01492972

Goserelin, 3.6mg, subcutaneous injection, q28d” NCT04220398

“leuprolide, goserelin, triptorelin acetate” NCT04181203

Goserelin: AstraZeneca, 10.8mg injection” NCT06772441

“Premenopause:Goserelin 3.6mg IM IM Q4W.” NCT04215003

“1. Goserelin(GnRHa) 3.6mg” NCT01622361

Goserelin 10.8 mg” NCT00223145

“Drug: GoserelinNCT00309478

GoserelinNCT05498272

GoserelinNCT04293393

GoserelinNCT05700903

GoserelinNCT07596212

NCT02430480

NCT06636591

NCT03671330

NCT03936218

NCT00771017

NCT06953882

NCT00002881

NCT00255268

NCT00653757

NCT05720260

NCT05004142

NCT01744366

NCT00012090

NCT00833248

NCT00432172

NCT04536467

NCT00003394

NCT01023061

NCT05607004

NCT00028769

NCT01750398

NCT04736108

NCT02592083

NCT00004635

NCT07552506

NCT05253066

NCT07552493

NCT07552480

NCT04551495

NCT00047099

NCT06455969

NCT00031850

NCT05513365

NCT02313051

NCT05212857

NCT00053911

NCT07179939

NCT00026377

NCT00002580

NCT07268794

NCT02789878

NCT00004124

NCT00605267

NCT00884273

NCT01530607

NCT00498901

NCT02914158

NCT06523530

NCT03447132

NCT00841113

NCT04356430

NCT02603679

NCT05594095

NCT00769795

NCT04248621

NCT01723774

NCT04478266

NCT00482807

NCT03936933

NCT02072512

NCT06387056

NCT03899077

NCT03475758

NCT03423199

NCT00014586

NCT00003653

NCT00055731

NCT01394263

NCT06378866

NCT02624973

NCT00002889

NCT00002633

NCT00388804

NCT00217659

NCT02115282

NCT03007979

NCT00767286

NCT00631527

NCT01964170

NCT03070886

NCT04862143

NCT06832774

NCT00235937

NCT01240941

NCT02476786

NCT01252693

NCT04894188

NCT03822468

NCT07287098

NCT00068601

NCT02278120

NCT01013506

NCT01581944

NCT00002582

NCT00439751

NCT04513717

NCT01377389

NCT03272477

NCT05161195

NCT05003752

NCT03860987

NCT02333370

NCT05050084

NCT03444025

NCT00298155

NCT00851461

NCT01989780

NCT06575257

NCT05582499

NCT03056755

NCT01738724

NCT00021450

NCT00827307

NCT00167648

NCT03628066

NCT00654524

NCT01266213

NCT00382057

NCT02661789

NCT02535221

NCT00108732

NCT02132390

NCT02917005

NCT01014507

NCT00002460

NCT00567580

NCT00541047

NCT00303784

NCT05163106

NCT02586675

NCT01496131

NCT06348134

NCT01218581

NCT02483767

NCT03839823

NCT04787744

NCT00293670

NCT00196846

NCT00912548

NCT03096847

NCT00293696

NCT00186121

NCT00427245

NCT00016913

NCT00651326

NCT01240928

NCT00398489

NCT02941926

NCT06225284

NCT07158021

NCT00831233

NCT00349557

NCT00429403

NCT01546987

NCT06145308

NCT06582446

NCT00532272

NCT05781217

NCT05827081

NCT00454571

NCT05694819

NCT02344472

NCT02907918

NCT01205685

NCT00348998

Known as GNRH-A Goserelin ClinicalTrials.gov intervention name — accepted as the source's own label NCT05617885
Known as goserelin acetate “Either leuprolide acetate (Lupron Depot, 22.5 mg or 45 mg IM), triptorelin pamoate (Trelstar, 11.25 mg or 22.5 mg IM), goserelin acetate (Zoladex, 10.8mg SC) or degarelix...” NCT03311555
80

“Patients receive multitargeted tyrosine kinase inhibitor PLX3397 orally (PO) twice daily (BID) for 6 months, undergo radiation therapy for 2 months daily (Monday-Friday)...” NCT02472275

“Primary Objective: * To determine the effectiveness of goserelin acetate (Zoladex) in preserving ovarian function in premenopausal women undergoing neoadjuvant and/or adjuvant...” NCT00429403

“All subjects will receive androgen deprivation therapy with a LHRH agonist (any LHRH agonist such as leuprolide acetate or goserelin acetate is acceptable) or a LHRH antagonist...” NCT02582749

“A GnRH analog (goserelin acetate, leuprolide acetate) will be administered for approximately 28 months: prior to radiotherapy (2 months), during radiotherapy (2 months), and...” NCT00099086

“The LHRH agonist (leuprolide acetate, goserelin acetate, or triptorelin pamoate) will be administered by injection once every 4 weeks on Day 1 of each 28-day cycle, according...” NCT03332797

Goserelin acetate implant (ZOLADEX), at a dose of 10.8 mg, will be administered subcutaneously every 12 weeks into the anterior abdominal wall below the navel line.” NCT07450599

“Subcutaneous injection of 3.6 mg of goserelin acetate once, administered 1 to 3 days prior to allogeneic haematopoietic stem cell transplantation conditioning.” NCT07552506

“either goserelin acetate at 3.6 mg subcutaneously or leuprolide acetate at 7.5 mg intramuscularly monthly for 6 months starting at Day 1 of therapy.” NCT00016913

“luteinizing hormone-releasing hormone (LHRH) agonists including leuprolide acetate and goserelin acetate as per Investigator's discretion.” NCT02217566

“3,6 mg of goserelin acetate (GnRH agonist) will be administered on the 21st day of the menstrual cycle previous to ovarian stimulation.” NCT00948805

“Patients will also receive androgen deprivation for 18-24 weeks of an LHRH agonist (eg, leuprolide acetate, goserelin acetate).” NCT00430183

“LHRH agonists may include, but are not limited to, leuprolide acetate, goserelin acetate, or triptorelin pamoate.” NCT04961996

“for example, leuprolide acetate 22.5mg IM or goserelin acetate 10.8mg SC given every 3 months for 2 doses” NCT01717053

“GnRH analog Goserelin acetate 3.6 mg every 4 weeks with tamoxifen 20 mg daily for premenopausal patients” NCT05755581

Goserelin acetate (Zoladex) is a gonadotropin-releasing hormone agonist (GnRH).” NCT06455969

goserelin acetate: 10.8mg given SC every 3 months for a total of 6 months” NCT00776594

Goserelin acetate (Zoladex) subcutaneously every 4 weeks” NCT04126070

Goserelin Acetate 10.8 MG Subcutaneous Implant” NCT03899077

“Leuprorelin acetate, goserelin acetateNCT05891093

Goserelin Acetate 3.6 mg inj, implant” NCT06523530

Goserelin acetate (Zoladex)” NCT00605267

“Drug: goserelin acetateNCT00541047

“Drug: Goserelin AcetateNCT00439751

“Drug: Goserelin AcetateNCT03070886

“Drug: goserelin acetateNCT00026377

goserelin acetateNCT03809000

NCT02023463

NCT04734730

NCT03678025

NCT02742675

NCT00536653

NCT01120236

NCT04455750

NCT00170157

NCT01149356

NCT00002651

NCT00433173

NCT00322348

NCT00328614

NCT00500110

NCT01163084

NCT07460752

NCT02168062

NCT03587285

NCT00849082

NCT00081159

NCT02278185

NCT00589472

NCT01242748

NCT00067015

NCT00114114

NCT04484818

NCT05439499

NCT01786265

NCT01776008

NCT05856630

NCT00104715

NCT00010010

NCT02779387

NCT01674140

NCT04423211

NCT02003209

NCT00946920

NCT00303524

NCT03361735

NCT00937768

NCT00544830

NCT04060043

NCT00888082

NCT02346253

NCT02107391

NCT00512668

NCT00769548

NCT00423475

NCT03373708

NCT03942653

NCT02058706

NCT02685397

NCT01368263

NCT05438810

Known as goserelin acetate (Zoladex) “goserelin acetate (Zoladex®)” NCT01531205
Known as Goserelin Depot “Drug: Goserelin DepotNCT07552506
Known as NSC-606864 “Flutamide, FLUT, NSC-147834; Goserelin, Zoladex, ZDX, NSC-606864; with irradiation of the whole pelvis followed by a boost to the prostate using photons of at least 6 MV.” NCT00769548
Known as ZDX “Flutamide, FLUT, NSC-147834; Goserelin, Zoladex, ZDX, NSC-606864; with irradiation of the whole pelvis followed by a boost to the prostate using photons of at least 6 MV.” NCT00769548
1

“luteinizing hormone-releasing hormone (LHRH) analog (buserelin [BSRL], goserelin [ZDX], or leuprolide [LEUP])” NCT00003653

Known as Zoladex “Either leuprolide acetate (Lupron Depot, 22.5 mg or 45 mg IM), triptorelin pamoate (Trelstar, 11.25 mg or 22.5 mg IM), goserelin acetate (Zoladex, 10.8mg SC) or degarelix...” NCT03311555
51

“Drug name: Zoladex Generic Name: Gonadotropin-releasing hormone analogue; Goserelin Proprietary Name: N/A Formulation: Solution for injection Dose: 3.6mg Frequency: Single...” NCT03054168

“Patients will continue on ADT with LHRH agonist (i.e. Zoladex, Trelstar, Eligard, or Lupron) or LHRH antagonist (Degarelix or Relugolix) if not surgically castrated throughout...” NCT06922318

“Patients in the combined-treatment group received 3.6 mg of goserelin (Zoladex) subcutaneously every four weeks starting on the first day of irradiation and continuing for three years” PMID 9233866 Jul 1997

“Choice of LHRHa per investigator discretion/site practice guidelines (e.g, Eligard®, Zoladex®, Lupron Depot®, Trelstar®) and ARN-509 Tablets, 240 mg/day administered orally” NCT01790126

“Flutamide, FLUT, NSC-147834; Goserelin, Zoladex, ZDX, NSC-606864; with irradiation of the whole pelvis followed by a boost to the prostate using photons of at least 6 MV.” NCT00769548

“CSD patients were treated with vaginal repair of CSD in combination with GnRHa (Zoladex, 3.6 mg, AstraZeneca, Macclesfield, United Kingdom) as a subcutaneous injection” NCT02932761

“Goserelin acetate implant (ZOLADEX), at a dose of 10.8 mg, will be administered subcutaneously every 12 weeks into the anterior abdominal wall below the navel line.” NCT07450599

“luteinizing hormone-releasing hormone (LHRH) agonist (i.e. Zoladex, Trelstar, Eligard, or Lupron) or LHRH antagonist (Degarelix or Relugolix)” NCT06059118

“monthly injections of a luteinizing hormone-releasing hormone (LHRH) analog such as Lupron or ZoladexNCT00283803

“group B received goserelin subcutaneosly (3.6 mg/month, Zoladex@, Zeneka Pharma International, UK)” NCT01218581

“Goserelin (Zoladex) plus Standard cyclophosphamide containing adjuvant or neoadjuvant chemotherapy” NCT01530607

“Lupron: 22.5mg IM injection q 12 wks x 2 OR Zoladex: 10.8 mg subQ injection q 12 wks x 2” NCT00006359

Zoladex is administered subcutaneously and Lupron is administered intramuscularly.” NCT00658697

“Groups 1-5 will receive goserelin acetate (Zoladex) plus 0 (placebo gel)” NCT00114114

“LHRH agonist or antagonist (e.g. Eligard, Zoladex, Lupron, Orgovyx)” NCT07142551

“bicalutamide (Casodex), goserelin (Zoladex)” NCT00293696

“AA: Lupron 22.5 mg or Zoladex 10.8 mg” NCT00970203

“2. Zoladex/ Flutamide” NCT02911350

“Goserelin (Zoladex)” NCT00293670

Zoladex®” NCT03809000

ZoladexNCT00005044

ZoladexNCT00165399

NCT00669162

NCT05898321

NCT02592031

NCT00116220

NCT03664895

NCT01250717

NCT06385847

NCT05140512

NCT01712893

NCT07310420

NCT06282588

NCT05013242

NCT05856630

NCT02678520

NCT00488722

NCT02594072

NCT02749825

NCT03971110

NCT03658213

NCT00286351

NCT04563936

NCT02626507

NCT00438321

NCT02059213

NCT01682642

NCT03440879

NCT03591549

NCT00002597

NCT03450109

Known as Zoladex LA ClinicalTrials.gov intervention name — accepted as the source's own label NCT01673984
Known as ZOLADEXTM “patients added Goserelin(ZOLADEXTM) to Tamoxifen” NCT00912548
Action Inhibit “Leuprolide and goserelin-both approved to treat prostate cancer-reduce testosterone production” NCT00004635
Modality Other / unclassified “Zoladex, a kind of luitinizing hormone releasing hormone analogue, can offer efficient estrogen suppression as well.” NCT00488722
Route Subcutaneous “goserelin subcutaneously (SC)” NCT00002580