drugset / Trial / NCT00028769
S0032, Combination Chemotherapy Plus Hormone Therapy in Treating Patients With Metastatic Prostate Cancer
NaSingle-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Androgens can stimulate the growth of prostate cancer cells. Drugs such as goserelin, leuprolide, flutamide, or bicalutamide may stop the adrenal glands from producing androgens. Combining chemotherapy with hormone therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy plus hormone therapy in treating patients who have metastatic prostate cancer.
Timeline
- Start
- 2001-12
- Primary completion
- 2010-06
- Completion
- 2011-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bicalutamide | Other / unclassified | — | Oral |
| Subject | Etoposide | Small molecule | — | Oral |
| Subject | Goserelin | Other / unclassified | — | Subcutaneous |
| Subject | Leuprolide | Other / unclassified | — | Intramuscular |
| Subject | Nilutamide | Small molecule | — | Oral |
| Subject | Paclitaxel | Small molecule | — | Intravenous |
| Subject | estramustine | Other / unclassified | — | Oral |
| Subject | flutamide | Small molecule | — | Oral |