drugset / Trial / NCT05253066
Chidamide Combined With Exemestane (+/- Goserelin) Versus Neoadjuvant Chemotherapy in Patients of Stage II-III HR-positive/HER2-negative Breast Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
This is an open, multicenter, randomized controlled clinical study aimed to explore the efficacy and safety of chidamide combined with exemestane (+/- goserelin) versus chemotherapy in the neoadjuvant treatment of stage II-III HR +/HER2- breast cancer patients with poor response to previous chemotherapy.
Timeline
- Start
- 2022-02-25
- Primary completion
- 2022-07-31
- Completion
- 2025-01-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Docetaxel | Small molecule | — | — |
| Comparator | Epirubicin | Small molecule | — | — |
| Subject | Exemestane | Small molecule | — | — |
| Subject | Goserelin | Other / unclassified | — | — |
| Subject | Tucidinostat | Small molecule | — | — |