Drugs / Tucidinostat
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Tucidinostat

Small molecule targets HDAC1, HDAC3 via inhibition

Developed for
peripheral T-cell lymphoma, not otherwise specified · diffuse large B-cell lymphoma · acute myeloid leukemia · breast cancer · colorectal cancer · mature T-cell and NK-cell non-Hodgkin lymphoma · hormone receptor-positive breast cancer · non-Hodgkin lymphoma
+72 more · non-small cell lung carcinoma · angioimmunoblastic T-cell lymphoma · HIV infectious disease · triple-negative breast carcinoma · extranodal nasal NK/T cell lymphoma · T-cell non-Hodgkin lymphoma · classic Hodgkin lymphoma · disease related to hematopoietic stem cell transplant · lymphoma · neuroendocrine carcinoma · relapsed/refractory diffuse large B-cell lymphoma · acute leukemia · acute monocytic leukemia · adenoid cystic carcinoma · adult acute lymphoblastic leukemia · adult T-cell leukemia/lymphoma · B-cell non-Hodgkin lymphoma · Ehrlich tumor carcinoma · Epstein-Barr virus infection · esophageal squamous cell carcinoma · female breast carcinoma · Her2-receptor negative breast cancer · melanoma · myelodysplastic syndrome · neuroblastoma · plasma cell myeloma · T lymphoblastic leukemia/lymphoma · T-cell leukemia · thrombocytopenia · acute lymphoblastic leukemia · acute promyelocytic leukemia · aggressive B-cell non-Hodgkin lymphoma · B-cell acute lymphoblastic leukemia · B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) · bone sarcoma · breast neoplasm · cancer · carcinoma of esophagus · cervical cancer · colon adenocarcinoma · Epstein-Barr virus-associated lymphoproliferative disorder · follicular lymphoma · gastric adenocarcinoma · gastroesophageal junction adenocarcinoma · head and neck squamous cell carcinoma · hemophagocytic syndrome · hepatocellular carcinoma · high-grade B-cell lymphoma double-hit/triple-hit · Hodgkins lymphoma · intrahepatic cholangiocarcinoma · large B-cell lymphoma · liver cancer · lung cancer · lymphoblastic lymphoma · malignant pancreatic neoplasm · mantle cell lymphoma · metastatic malignant neoplasm in the brain · metastatic melanoma · myeloid neoplasm · nasopharyngeal carcinoma · Nodal T-follicular helper cell lymphoma, follicular type · osteosarcoma · pancreatic ductal adenocarcinoma · primary central nervous system lymphoma · primary cutaneous T-cell lymphoma · refractory malignant neoplasm · renal cell carcinoma · sarcoma · small cell lung carcinoma · soft tissue sarcoma · T-cell/histiocyte rich large B cell lymphoma · urinary bladder cancer
Investigated by
Sun Yat-sen University · Ruijin Hospital · Chinese PLA General Hospital · Chipscreen Biosciences, Ltd. · The First Affiliated Hospital of Soochow University · The First Affiliated Hospital with Nanjing Medical University
+151 more · Tianjin Medical University Cancer Institute and Hospital · Peking Union Medical College Hospital · Fudan University · HUYABIO International, LLC. · Nanfang Hospital, Southern Medical University · The First Affiliated Hospital of Xiamen University · Fujian Cancer Hospital · Sichuan University · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Huizhou Municipal Central Hospital · Institute of Hematology & Blood Diseases Hospital, China · Peking University · 940 Hospital of the People's Liberation Army Joint Logistic Support Force · 960th Hospital of Joint Logistics Support Force of People's Liberation Army of China · Dongguan People's Hospital · Guangdong Provincial People's Hospital · Jining Medical University · The First Affiliated Hospital of Zhengzhou University · The First Hospital of Jilin University · The General Hospital of Western Theater Command · Chinese Academy of Medical Sciences · First Affiliated Hospital of Harbin Medical University · First Affiliated Hospital of Zhejiang University · Fujian Provincial Hospital · Henan Cancer Hospital · Jieyang People's Hospital · Mingzhi Zhang · Ou Bai, MD/PHD · Peking University Cancer Hospital & Institute · Peking University Third Hospital · Shanxi Province Cancer Hospital · The Affiliated Hospital of Xuzhou Medical University · The First Affiliated Hospital of Bengbu Medical University · West China Hospital · Yantai Yuhuangding Hospital · Affiliated Hospital of Nantong University · Air Force Military Medical University, China · Beijing 302 Hospital · Beijing Longfu Hospital · First Affiliated Hospital of Ningbo University · First Hospital of China Medical University · Great Novel Therapeutics Biotech & Medicals Corporation · Guangdong Association of Clinical Trials · Harbin Medical University · Huiqiang Huang · Hunan Cancer Hospital · IQVIA Pty Ltd · Liaoning Cancer Hospital & Institute · Northern Jiangsu People's Hospital · Peking University International Hospital · People's Liberation Army (PLA) Strategic Support Force Characteristic Medical Center · Qilu Hospital of Shandong University · Shandong University · Shengjing Hospital · Tang-Du Hospital · The First Affiliated Hospital of Anhui Medical University · The General Hospital of Northern Theater Command · The Second People's Hospital of Huai'an · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Xinqiao Hospital of Chongqing · Yuankai Shi · Zhangzhou Affiliated Hospital of Fujian Medical University · Zhangzhou manicipal hospital of Fujian Province · Zhejiang Cancer Hospital · Zhejiang University · wang shusen · Air Force Medical Center of PLA · Akesobio · Anhui Provincial Cancer Hospital · Anhui Provincial Hospital · Ascentage Pharma Group Inc. · Beijing Friendship Hospital · Beijing Tongren Hospital · Biyun Wang, MD · all 157 on the full record

Trials 254 · started per year

today
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2013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT07598578 Jun 2026 → Jan 2030 expected peripheral T-cell lymphoma, not otherwise specified Second Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 110 trials
Phase 1 NCT07635992 Jun 2026 → Dec 2028 expected HIV infectious disease First Affiliated Hospital of Zhejiang University Not yet recruiting No outcome recorded
Phase 1 NCT07545967 Apr 2026 → Jul 2027 expected head and neck squamous cell carcinoma West China Hospital Recruiting No outcome recorded
Phase 1 NCT05586841 Oct 2022 → Dec 2025 hormone receptor-positive breast cancer Beijing 302 Hospital Completed No outcome recorded
Phase 1 NCT05281276 Sep 2022 → Mar 2024 colorectal cancer Taipei Medical University Shuang Ho Hospital Terminated No outcome recorded
Phase 1 NCT05338541 May 2022 → Jun 2024 neuroblastoma Yizhuo Zhang Unknown No outcome recorded
Phase 1 NCT05083208 Feb 2022 → Jun 2024 peripheral T-cell lymphoma, not otherwise specified Henan Cancer Hospital Terminated No outcome recorded
Phase 1 NCT03980691 Dec 2017 → May 2020 HIV infectious disease Guangzhou 8th People's Hospital Completed No outcome recorded
Phase 1 NCT02809573 Aug 2016 → Jan 2019 peripheral T-cell lymphoma, not otherwise specified Chipscreen Biosciences, Ltd. Completed No outcome recorded
Phase 1 NCT02569489 Dec 2015 breast cancer HUYABIO International, LLC. Withdrawn No outcome recorded
Phase 1 NCT02697552 Mar 2014 → Oct 2016 non-Hodgkin lymphoma HUYABIO International, LLC. Completed No outcome recorded
Phase 1/243 trials
Phase 1/2 NCT07706959 Jul 2026 → Jan 2028 expected peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07601607 May 2026 → May 2028 expected relapsed/refractory diffuse large B-cell lymphoma Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT07577986 May 2026 → May 2027 expected HIV infectious disease First Affiliated Hospital of Zhejiang University Not yet recruiting No outcome recorded
Phase 1/2 NCT07415980 Apr 2026 → Apr 2028 expected diffuse large B-cell lymphoma Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT07320963 Mar 2026 → Mar 2027 expected nasopharyngeal carcinoma Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT07493330 Mar 2026 → Dec 2029 expected refractory malignant neoplasm Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07339527 Jan 2026 → Jan 2028 expected mature T-cell and NK-cell non-Hodgkin lymphoma Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT07139353 Sep 2025 → Sep 2027 expected peripheral T-cell lymphoma, not otherwise specified Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT07133763 Sep 2025 → Sep 2027 expected Epstein-Barr virus-associated lymphoproliferative disorder The Affiliated Hospital of Xuzhou Medical University Not yet recruiting No outcome recorded
Phase 1/2 NCT07133776 Sep 2025 → Sep 2027 expected Epstein-Barr virus infection The Affiliated Hospital of Xuzhou Medical University Not yet recruiting No outcome recorded
Phase 2159 trials
Phase 2 NCT07616336 Jul 2026 → Mar 2027 expected myelodysplastic syndrome Zhongshan Hospital (Xiamen), Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT07643636 Jun 2026 → Jun 2028 expected acute myeloid leukemia Dongguan People's Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07507318 Jun 2026 → Jun 2029 expected diffuse large B-cell lymphoma Rong Tao Recruiting No outcome recorded
Phase 2 NCT07412262 May 2026 → Mar 2028 expected non-small cell lung carcinoma Guangdong Association of Clinical Trials Not yet recruiting No outcome recorded
Phase 2 NCT07602322 May 2026 → May 2028 expected large B-cell lymphoma Ruijin Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07552324 May 2026 → May 2027 expected T-cell/histiocyte rich large B cell lymphoma Ruijin Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07493148 Apr 2026 → Dec 2029 expected diffuse large B-cell lymphoma Ou Bai, MD/PHD Recruiting No outcome recorded
Phase 2 NCT07651475 Mar 2026 overdue acute myeloid leukemia Liping Dou Active not recruiting No outcome recorded
Phase 2 NCT07518602 Mar 2026 → Mar 2028 expected neuroendocrine carcinoma Sun Yat-sen University Recruiting No outcome recorded
Phase 2 NCT07570849 Mar 2026 → Jun 2027 expected intrahepatic cholangiocarcinoma Shanghai Zhongshan Hospital Recruiting No outcome recorded
Show all 159 trials opens the full record — a long page
Phase 2/35 trials
Phase 2/3 NCT05253066 Feb → Jul 2022 breast neoplasm Shengjing Hospital Unknown No outcome recorded
Phase 2/3 NCT02902185 Nov 2016 → Aug 2018 Tang-Du Hospital Unknown No outcome recorded
Phase 2/3 NCT03564704 Feb 2016 → May 2021 T-cell leukemia, adult acute lymphoblastic leukemia, lymphoblastic lymphoma Nanfang Hospital, Southern Medical University Unknown No outcome recorded
Phase 2/3 NCT03553238 Feb 2016 → May 2020 T lymphoblastic leukemia/lymphoma, T-cell leukemia, acute leukemia Nanfang Hospital, Southern Medical University Unknown No outcome recorded
Phase 2/3 NCT03564470 Feb 2016 → Aug 2023 B-cell acute lymphoblastic leukemia Nanfang Hospital, Southern Medical University Unknown No outcome recorded
Phase 315 trials
Phase 3 NCT07639879 Jul 2026 → Jul 2029 expected mature T-cell and NK-cell non-Hodgkin lymphoma Tarapeutics Science Inc. Not yet recruiting No outcome recorded
Phase 3 NCT07493109 May 2026 → Sep 2029 expected diffuse large B-cell lymphoma Ou Bai, MD/PHD Recruiting No outcome recorded
Phase 3 NCT06947967 Aug 2025 → Dec 2032 expected peripheral T-cell lymphoma, not otherwise specified Chipscreen Biosciences, Ltd. Recruiting No outcome recorded
Phase 3 NCT06776952 Apr 2025 → Jan 2028 expected peripheral T-cell lymphoma, not otherwise specified Evopoint Biosciences Inc. Recruiting No outcome recorded
Phase 3 NCT06497985 Dec 2024 → May 2028 expected colorectal cancer Chipscreen Biosciences, Ltd. Recruiting No outcome recorded
Phase 3 NCT06255795 Feb 2024 → Dec 2026 expected mature T-cell and NK-cell non-Hodgkin lymphoma Ruijin Hospital Not yet recruiting No outcome recorded
Phase 3 NCT06122389 Feb 2024 → May 2026 overdue peripheral T-cell lymphoma, not otherwise specified Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT05768503 Mar 2023 → Jan 2026 overdue colorectal cancer Sun Yat-sen University Recruiting No outcome recorded
Phase 3 NCT05678933 Jan 2023 → Dec 2027 expected peripheral T-cell lymphoma, not otherwise specified Tianjin Medical University Cancer Institute and Hospital Enrolling by invitation No outcome recorded
Phase 3 NCT05466318 Jul 2022 → Dec 2025 T-cell non-Hodgkin lymphoma, diffuse large B-cell lymphoma Sichuan University Unknown No outcome recorded
Phase 44 trials
Phase 4 NCT05191914 Feb → Jul 2022 breast cancer Liaoning Cancer Hospital & Institute Unknown No outcome recorded
Phase 4 NCT04040491 Sep 2019 → Dec 2020 peripheral T-cell lymphoma, not otherwise specified Mingzhi Zhang Unknown No outcome recorded
Phase 4 NCT04038411 Apr 2019 → Apr 2021 mature T-cell and NK-cell non-Hodgkin lymphoma Mingzhi Zhang Unknown No outcome recorded
Phase 4 NCT04490590 Oct 2016 → Oct 2020 mature T-cell and NK-cell non-Hodgkin lymphoma Mingzhi Zhang Unknown No outcome recorded
Phase not applicable17 trials
NCT07521124 Jun 2026 → Jun 2029 expected acute myeloid leukemia Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Not yet recruiting No outcome recorded
NCT07542912 Jun 2026 → Jun 2029 expected Sun Yat-sen University Not yet recruiting No outcome recorded
NCT07072221 Nov 2024 → Aug 2029 expected peripheral T-cell lymphoma, not otherwise specified The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
NCT07074457 Nov 2024 → Aug 2028 expected peripheral T-cell lymphoma, not otherwise specified The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
NCT06386302 Aug 2024 → Dec 2027 expected acute myeloid leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
NCT06066905 Oct 2023 → Dec 2026 expected acute myeloid leukemia Guangdong Provincial People's Hospital Recruiting No outcome recorded
NCT06211881 Oct 2023 → Sep 2025 mature T-cell and NK-cell non-Hodgkin lymphoma The First Affiliated Hospital with Nanjing Medical University Unknown No outcome recorded
NCT05890287 May 2023 → May 2026 overdue hormone receptor-positive breast cancer Tianjin Medical University Cancer Institute and Hospital Recruiting No outcome recorded
NCT05784987 Apr 2023 → Jan 2024 diffuse large B-cell lymphoma The First Affiliated Hospital with Nanjing Medical University Unknown No outcome recorded
NCT05896813 Mar 2023 → Jan 2025 peripheral T-cell lymphoma, not otherwise specified The First Affiliated Hospital with Nanjing Medical University Unknown No outcome recorded
Also used as a comparator or background therapy in 5 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 23 trials
Phase 2 NCT07058103 Background Apr 2025 → Apr 2028 expected angioimmunoblastic T-cell lymphoma The Affiliated Hospital of Xuzhou Medical University Recruiting No outcome recorded
Phase 2 NCT06701357 Background Dec 2024 → Dec 2026 expected diffuse large B-cell lymphoma Ruijin Hospital Recruiting No outcome recorded
Phase 2 NCT03602131 Background Jan 2019 → Dec 2020 Hodgkins lymphoma, non-Hodgkin lymphoma Sichuan University Unknown No outcome recorded
Phase 32 trials
Phase 3 NCT07234162 Comparator May 2024 → Nov 2027 expected peripheral T-cell lymphoma, not otherwise specified Dizal Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT04668690 Comparator Apr 2021 → Dec 2027 expected peripheral T-cell lymphoma, not otherwise specified CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Active not recruiting No outcome recorded

Evidence & citations 15 cited values

Every value below carries the sentence it was read from. 266 sources stand behind the page.

FieldValueCited text
Known as tucidinostat “our previous study found that HDACi tucidinostat/chidamide could restore the expression and functionality of IKZF1 in IKZF1del samples, including increased expression of CD19...” NCT06220487
20

“Oral histone deacetylase inhibitor tucidinostat (HBI-8000) in patients with relapsed or refractory adult T-cell leukemia/lymphoma: Phase IIb results.” PMID 35579212 Jun 2022

Tucidinostat (formerly known as chidamide) is an oral subtype-selective histone deacetylase inhibitor.” PMID 31036468 Apr 2019

“oral HDACI tucidinostat (formerly known as chidamide)” PMID 33097085 Oct 2020

NCT05519865

NCT06547476

NCT04661943

NCT06947967

NCT05335473

NCT05075460

NCT04999540

NCT05338541

NCT05390476

NCT05411380

NCT05163483

NCT06125171

NCT05559008

NCT06497985

NCT04465097

NCT05633914

NCT04231448

Known as Chi Chidamide (Chi)+VAH” NCT07643636
Known as chidamide “Using the combined regimen of CHiR (chidamide, zanubrutinib, and lenalidomide) to treat newly diagnosed elderly patients with MYC- and BCL2-expressing positive diffuse large...” NCT06764017
239

“The combination of ASC22, an anti-PD-L1 antibody potentially enhancing HIV-specific immunity and chidamide, a HIV latency reversal agent, may serve as a strategy for...” PMID 39245675 Sep 2024

“This phase II study was designed to assess the efficacy and safety of the combination of Apatinib, Tucidinostat (chidamide), a histone deacetylase inhibitor in relapsed or...” NCT06125171

“Investigator's choice treatment with chidamide, golidocitinib, mitoxantrone hydrochloride liposome, or gemcitabine hydrochloride administered according to the respective...” NCT07639879

Chidamide 20 mg orally;gemcitabine 1g/m2, twice a week, intravenous infusion on day 1, vinorelbine 20 mg/m2, infusion on day 1; Mitoxantrone Hydrochloride Liposome12 mg/m2,...” NCT06211881

“Patients received rituximab (375 mg/m2 intravenously on Day 1), lenalidomide (15 mg orally on Days 1-21), and chidamide (30 mg orally twice weekly) in 28-day cycles for up to 6 cycles.” PMID 42124356 May 2026

Chidamide: Administered at the maximum tolerated dose/recommended phase II dose (MTD/RP2D), orally twice weekly (on Days 1, 4, 8, 11, 15, and 18 of each cycle), 30 minutes after meals.” NCT06858969

“The treatment option for the chidamide + sintilimab + bevacizumab (study group) is 200 mg of sintilimab IV Drip Q3W, 30 mg of chidamide PO BIW, and bevacizumab 7.5 mg/kg IV Drip Q3W” NCT05768503

“10 mg/kg UB-421 weekly intravenous infusion to substitute for antiretroviral therapy, and combined with oral 10 mg chidamide twice a week for 8 weeks.” NCT04985890

“R 375 mg/m2 D1 Pola 1.8mg/kg D1 CTX 750mg/m2 D2 ADR 50mg/m2 D2 Pred 60 mg/m2 D2-6 Chidamide 20mg/d D1,4,8,11 Lisaftoclax 600mg/d D1-21” NCT07552324

“Tucidinostat (chidamide),30mg, po., biw PD-1 inhibitor (tislelizumab), 200mg, ivgtt. d1, q3w anlotinib, 12mg, po., d1-14, q3w” NCT06547476

“Tucidinostat (formerly known as chidamide) is an oral subtype-selective histone deacetylase inhibitor.” NCT04231448

“treated with cycle 2-6 R-CHOP in combination with obutinib or decitabine or lenalidomide or Chidamide.” NCT06748521

Chidamide 30mg ,twice a week Prednisone 20mg qd Cyclophosphamide 50mg qd Thalidomide 100mg qd” NCT02879526

“Introduction treatment: Rituximab, lenalidomide, chidamide for 2 cycles:” NCT06674096

Chidamide 30mg orally twice every week for 2 weeks on days 1, 4, 8, 11” NCT05029141

Chidamide 30mg orally twice every week for 2 weeks on days 1, 4, 8, 11” NCT03985007

Chidamide is an oral subtype-selective histone deacetylase inhibitor.” NCT06890585

Chidamide 20mg/day po D1,4,8,11 if with CREBBP/EP300 gene mutation.” NCT04480099

Chidamide; Specification: 5mg per tablet; 20mg biw for 2 weeks, po.” NCT07072221

Chidamide: Chidamide is administered orally at a dose of 30mg” NCT04512534

“DE Type: Glofitamab + HDAC inhibitor (e.g., Chidamide)” NCT07602322

Chidamide 30mg PO twice weekly (days 1,4,8,11,14,18)” NCT07538180

Chidamide 20 mg is administered orally twice weekly.” NCT07598578

“Drug: Chidamide 30 mg oral twice weekly for 2 weeks” NCT05807659

Chidamide (C): 5 mg, orally, once daily, Days 1-14” NCT07521124

“Drug: Chidamide chidamide 30mg orally,Biw” NCT05191914

“4. Chidamide (30 mg/day , days 1,4,8,11).” NCT07512700

Chidamide: 10mg orally daily for 12 days” NCT06532552

Chidamide (30mg, biw, D1-21)” NCT07542912

Chidamide 20 mg/d D1,4,8,11” NCT06750991

“For EZB: Chidamide 30mg biw” NCT06758037

chidamide P.O. 30mg twice/W” NCT03453255

Chidamide 20mg/d D1,4,8,11” NCT06701357

“Tucidinostat (chidamide)” NCT05163483

NCT07415980

NCT05808582

NCT07570849

NCT04984018

NCT06570447

NCT05632848

NCT05186545

NCT06220162

NCT07320963

NCT04025931

NCT04337606

NCT07514936

NCT05566054

NCT07601607

NCT07373964

NCT03980691

NCT01836679

NCT04022005

NCT05586841

NCT03336632

NCT02513901

NCT06930118

NCT04414969

NCT04582955

NCT04831710

NCT05527275

NCT07493109

NCT07493148

NCT04724239

NCT05770882

NCT07081607

NCT07380984

NCT05270200

NCT04329130

NCT04490590

NCT05367856

NCT05088226

NCT05320640

NCT07133763

NCT05075681

NCT07133776

NCT05823701

NCT07234162

NCT03023358

NCT04553393

NCT05784987

NCT07493330

NCT05137522

NCT02902185

NCT06083701

NCT02856997

NCT06550336

NCT05140616

NCT03629873

NCT05603884

NCT03553238

NCT05348213

NCT02987244

NCT05305859

NCT03598959

NCT06218888

NCT07339527

NCT06158386

NCT05281276

NCT05495100

NCT05047848

NCT05068427

NCT06745193

NCT05438706

NCT05958719

NCT06516978

NCT07318831

NCT06563778

NCT02733380

NCT06220487

NCT06556862

NCT07139353

NCT06037239

NCT02815007

NCT06709885

NCT05083208

NCT06393361

NCT02944812

NCT07093710

NCT04480125

NCT05527912

NCT06891157

NCT03564704

NCT03245905

NCT04516655

NCT04025450

NCT06750848

NCT05330364

NCT04233294

NCT03639168

NCT07518602

NCT05411874

NCT04040491

NCT03974243

NCT07643636

NCT05896813

NCT06492629

NCT04296786

NCT03605056

NCT07058103

NCT06951997

NCT03617432

NCT06928376

NCT05881265

NCT06408623

NCT06084819

NCT04025593

NCT06451861

NCT06739395

NCT05976997

NCT06122389

NCT02753647

NCT06386302

NCT03273452

NCT05572983

NCT03602131

NCT04651127

NCT05747313

NCT03494634

NCT07635992

NCT03838354

NCT05464173

NCT05678933

NCT07616336

NCT07412262

NCT04192903

NCT04038411

NCT07397832

NCT07577986

NCT05113355

NCT06637007

NCT05191914

NCT05186012

NCT07545967

NCT02753543

NCT07159620

NCT06066905

NCT05466318

NCT06979908

NCT03373019

NCT05478473

NCT05682755

NCT05253066

NCT03321890

NCT05675813

NCT07168317

NCT07706959

NCT02886559

NCT05806047

NCT05991973

NCT03151876

NCT03574402

NCT05890287

NCT04052659

NCT05008666

NCT03201471

NCT07074457

NCT05400993

NCT04668690

NCT02883374

NCT04994210

NCT07507318

NCT06151106

NCT03611231

NCT05983107

NCT06757387

NCT02809573

NCT03105596

NCT03564470

NCT04562311

NCT05076786

NCT04514081

NCT03410004

NCT03268889

NCT05659992

NCT05833724

NCT03853044

NCT06087419

NCT07489989

NCT05056974

NCT06421948

NCT03031262

NCT05085626

NCT07304232

NCT05749575

NCT06584227

NCT05179213

NCT03630731

NCT05951855

NCT02482753

NCT02878278

NCT05370547

NCT07651475

NCT05115409

NCT06776952

NCT03820596

NCT06255795

NCT04511351

NCT06685276

NCT06068621

Known as Chidamide (Tucidinostat) Chidamide (Tucidinostat)NCT05632848
Known as CS055 “Though it has been demonstrated that Chidamide (CS055/HBI-8000), a novel benzamide class of histone deacetylase (HDAC) subtype-selectively inhibitor, reveals better anticancer...” PMID 32653824 Jul 2020
1

“Chidamide (CS055/HBI-8000) is a new benzamide class of histone deacetylase inhibitor” PMID 22362161 Feb 2012

Known as CS055/HBI-8000 “chidamide (CS055/HBI-8000), a new member of the benzamide class of HDACi.” NCT03023358
Known as Epidaza “Participants will take oral chidamide (Epidaza) until 180 days after allo-HSCT.” NCT05682755
Known as Epidaza in china ChEMBL registry synonym — accepted as the source's own label CHEMBL3621988
Known as HBI-8000 “Though it has been demonstrated that Chidamide (CS055/HBI-8000), a novel benzamide class of histone deacetylase (HDAC) subtype-selectively inhibitor, reveals better anticancer...” PMID 32653824 Jul 2020
8

“Oral histone deacetylase inhibitor tucidinostat (HBI-8000) in patients with relapsed or refractory adult T-cell leukemia/lymphoma: Phase IIb results.” PMID 35579212 Jun 2022

“Chidamide (CS055/HBI-8000) is a new benzamide class of histone deacetylase inhibitor” PMID 22362161 Feb 2012

NCT05141357

NCT02697552

NCT02718066

NCT02953652

NCT02569489

NCT04674683

Known as Ocalivumab “For MCD/BN2/TP53: Ocalivumab 150mg qd” NCT06758037
Known as tudicdinostat “For HBI-8000: tudicdinostat; For nivolumab: OPDIVO®” NCT04674683
Action Inhibit “Tucidinostat (formerly known as chidamide) is an oral subtype-selective histone deacetylase inhibitor.” PMID 31036468 Apr 2019
Modality Small molecule “Chidamide is a novel benzamide chemical class of HDAC inhibitor” PMID 24721323 Mar 2014
Route Oral “Given orally” NCT01836679
Target HDAC1 “Chidamide was found to be a low nanomolar inhibitor of HDAC1, 2, 3, and 10” PMID 22080169 Nov 2011