drugset / Trial / NCT07058103
Tislelizumab , Cyclophosphamide, Mitoxantrone Liposomes, Chidamide, and Prednisone in the Treatment of R/R AITL
NaSingle-groupOpen-labelTreatment
Summary
Angioimmunoblastic T cell lymphoma (AITL) is a rare and aggressive lymphoma. Some patients relapsed after initial treatment or did not respond to standard treatment (refractory). Subsequent treatment options are limited and the efficacy is not ideal. This study attempts to explore the possibility of improving the efficacy of immunotherapy combined with chemotherapy and epigenetic regulatory drugs.
Timeline
- Start
- 2025-04-01
- Primary completion
- 2028-04-01
- Completion
- 2028-04-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Cyclophosphamide | Other / unclassified | 750 mg/m2 | — |
| Background | Mitoxantrone | Small molecule | 20 mg/m2 | — |
| Background | Prednisone | Other / unclassified | 100 mg | — |
| Background | Tislelizumab | Monoclonal antibody | 200 mg | — |
| Background | Tucidinostat | Small molecule | 20 mg | — |