drugset / Trial / NCT07601607

Lisaftoclax Plus Chidamide and Rituximab in Relapsed or Refractory Diffuse Large B-cell Lymphoma

NCT07601607

Phase 1/2 Not yet recruiting 51 enrolled Sun Yat-sen University
NaSingle-groupOpen-labelTreatment

Summary

This is a phase 1b/2a, open-label trial to evaluate the safety, pharmacokinetics, and preliminary efficacy of lisaftoclax in combination with chidamide and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL).

Timeline

Start
2026-05-30
Primary completion
2028-05-30
Completion
2028-11-30

Drugs

EvaluationDrugModalityDoseRoute
Subject APG-2575 Small molecule 600 mg Oral
Subject APG-2575 Small molecule 800 mg Oral
Subject Rituximab Monoclonal antibody 375 mg/m2 Intravenous
Subject Tucidinostat Small molecule 20 mg Oral