drugset / Trial / NCT03363659
Disulfiram and Copper Gluconate With Temozolomide in Unmethylated Glioblastoma Multiforme
NaSingle-groupOpen-labelTreatment
Summary
One of Disulfiram antitumor effects suggested in preclinical studies is MGMT (methyl-guanine-methyl-transferase) inhibition. Disulfiram MGMT inhibitory effect is enhanced by addition of Copper. This study evaluates the impact of Disulfiram (DSF) + Copper (Cu) combination when added to standard Temozolomide in the treatment of unmethylated Glioblastoma Multiforme (GBM) patients.
Timeline
- Start
- 2018-03-28
- Primary completion
- 2022-01-13
- Completion
- 2022-01-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Disulfiram | Small molecule | 125 mg | Oral |
| Background | Temozolomide | Small molecule | 150 mg/m2 | Oral |