drugset / Trial / NCT03382574

Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy

NCT03382574

Phase 0 Terminated 2 enrolled National Cancer Institute (NCI)
RandomizedParallel-groupOpen-labelPrevention

Summary

This randomized pilot early phase I trial studies how well denosumab works in BRCA1/2 mutations carriers scheduled for risk-reducing salpingo-oophorectomy. Denosumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread.

Timeline

Start
2019-03-14
Primary completion
2021-10-22
Completion
2021-10-22

Drugs

EvaluationDrugModalityDoseRoute
Subject Denosumab Monoclonal antibody 120 mg Subcutaneous

Indications