drugset / Trial / NCT03383068
Research of Intensive Metabolic Intervention Before Pregnancy in PCOS
RandomizedParallel-groupOpen-labelTreatment
Summary
To investigate whether intensive metabolic intervention of PCOS women before pregnancy can improve pregnancy outcome.Besides, the investigators aim to investigate the best therapy strategy of metabolic intervention before pregnancy.The investigators plan to recruit PCOS women at childbearing age. By using acarbose, GLP-1 analogue, berberin et al. the investigators will intervent the participants' metabolic statues for 3 months before pregnancy and to compare outcome in each group.
Timeline
- Start
- 2018-01-01
- Primary completion
- 2018-12-31
- Completion
- 2020-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acarbose | Unknown | 100 mg | — |
| Subject | Exenatide | Peptide | 10 ug | — |
| Subject | Orlistat | Small molecule | 0.12 mg | — |
| Background | Metformin | Small molecule | 1000 mg | — |
| Background | Metformin | Small molecule | 1500 mg | — |