drugset / Trial / NCT03383068

Research of Intensive Metabolic Intervention Before Pregnancy in PCOS

NCT03383068

Phase 4 Unknown 160 enrolled RenJi Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

To investigate whether intensive metabolic intervention of PCOS women before pregnancy can improve pregnancy outcome.Besides, the investigators aim to investigate the best therapy strategy of metabolic intervention before pregnancy.The investigators plan to recruit PCOS women at childbearing age. By using acarbose, GLP-1 analogue, berberin et al. the investigators will intervent the participants' metabolic statues for 3 months before pregnancy and to compare outcome in each group.

Timeline

Start
2018-01-01
Primary completion
2018-12-31
Completion
2020-06-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Acarbose Unknown 100 mg
Subject Exenatide Peptide 10 ug
Subject Orlistat Small molecule 0.12 mg
Background Metformin Small molecule 1000 mg
Background Metformin Small molecule 1500 mg