drugset / Trial / NCT03383783

Evaluation of the Fluoride Dose Response of a Modified In Situ Caries Model

NCT03383783

Phase 3 Completed 28 enrolled Domenick Zero GlaxoSmithKline · collab
RandomizedCrossoverDouble-blindOther

Summary

The purpose of this study is to evaluate the fluoride dose response of different dentifrice fluoride concentrations - 0, 250, 500 and 1100 ppm fluoride of our existing in situ model involving the use of human enamel specimens placed in the buccal flange area of the subjects partial denture with the modified model involving placement of bovine enamel specimens in a denture tooth location.

Timeline

Start
2017-12-19
Primary completion
2018-05-02
Completion
2018-05-02

Drugs

EvaluationDrugModalityDoseRoute
Subject sodium fluoride Unknown 250 ppm Topical
Subject sodium fluoride Unknown 500 ppm Topical
Subject sodium fluoride Unknown 1100 ppm Topical

Indications