drugset

drugset / Trial / NCT03400826

Effects of Simvastatin on Uterine Leiomyoma Size

NCT03400826 ↗

Phase 2 Recruiting 60 enrolled Johns Hopkins University Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · collab National Institutes of Health (NIH) · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The study aims to study the effect of simvastatin on the size of uterine fibroids.

Timeline

Start: 2018-08-20
Primary completion: 2026-07-31
Completion: 2026-07-31

Publications

Britten J, Roura-Monllor JA, Malik M, Moran S, DeAngelis A, Driggers P, Afrin S, Borahay M, Catherino WH. Simvastatin induces degradation of the extracellular matrix in human leiomyomata: novel in vitro, in vivo, and patient level evidence of matrix metalloproteinase involvement. F S Sci. 2024 Feb;5(1):80-91. doi: 10.1016/j.xfss.2023.11.005. Epub 2023 Dec 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Simvastatin	Small molecule	40 mg	Oral

Indications