Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients

Summary

To investigate the effects of different sedation protocols on skeletal muscle metabolism in mechanical ventilated patients in ICU. Mechanical ventilated patients who are anticipated to stay in ICU for more than 5 days are enrolled and randomly assigned to the following three groups, interventional group(dexmedetomidine), control group(midazolam) and no sedation group. Serum, CT scan of intercostal muscles, ultrasound evaluation of quadriceps femoris are obtained.

Timeline

Start

2017-12-20

Primary completion

2018-10-31

Completion

2019-01-31

Drugs

Indications