drugset / Trial / NCT03411798
Sequential Application of Yisaipu® and DMARDs in Treating Mild-to-Moderate AS
SequentialOpen-labelTreatment
Summary
The drug regimes in treating ankylosing spondylitis(AS) have limitations. The tumor necrosis factor inhibitors(TNFi) was effective but expensive. Disease modifying anti-rheumatic drugs (DMARDs) were cheap but insufficient. This study proposed a sequential usage of TNFi, the Yisaipu®, and DMARDs, and aims to evaluate the mid-term therapeutic effect of this new scheme in treating the mild-to-moderate AS.
Timeline
- Start
- 2017-12-15
- Primary completion
- 2019-07-01
- Completion
- 2019-07-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Hydroxychloroquine | Small molecule | — | — |
| Subject | Methotrexate | Small molecule | — | — |
| Subject | Sulfasalazine | Small molecule | — | — |
| Subject | YISAIPU | Protein / enzyme biologic | — | — |