drugset / Trial / NCT03411798

Sequential Application of Yisaipu® and DMARDs in Treating Mild-to-Moderate AS

NCT03411798

Phase 4 Completed 76 enrolled Nanfang Hospital, Southern Medical University
SequentialOpen-labelTreatment

Summary

The drug regimes in treating ankylosing spondylitis(AS) have limitations. The tumor necrosis factor inhibitors(TNFi) was effective but expensive. Disease modifying anti-rheumatic drugs (DMARDs) were cheap but insufficient. This study proposed a sequential usage of TNFi, the Yisaipu®, and DMARDs, and aims to evaluate the mid-term therapeutic effect of this new scheme in treating the mild-to-moderate AS.

Timeline

Start
2017-12-15
Primary completion
2019-07-01
Completion
2019-07-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Hydroxychloroquine Small molecule
Subject Methotrexate Small molecule
Subject Sulfasalazine Small molecule
Subject YISAIPU Protein / enzyme biologic