The Effects of Dexmedetomidine on Intravenous Anesthetic Requirements for Children Undergoing Dental Procedures

Summary

The investigators propose to determine the propofol and remifentanil sparing effects of a single dose of dexmedetomidine in the dental population. The investigators plan to do this by performing a blinded study with 4 test groups (3 experimental and 1 control), using BIS monitoring to titrate TIVA infusion to an acceptable depth of anesthesia.

Timeline

Start

2018-03-14

Primary completion

2021-04-01

Completion

2021-04-01

Outcome

Met primary endpoint

paper The median [interquartile range] propofol infusion rate was lower in the 1 mcg/kg dexmedetomidine group (180 [164-185] mcg/kg/min) versus placebo (200 [178-220] mcg/kg/min): PMID 39193655 ↗

paper p = 0.013. PMID 39193655 ↗

paper The remifentanil infusion rate was also lower in the 1 mcg/kg dexmedetomidine group (0.089 [0.080, 0.095] mcg/kg/min) versus placebo (0.103 [0.095, 0.106] PMID 39193655 ↗

paper p = .022. PMID 39193655 ↗

Publications

• Lee VCL, Ridgway R, West NC, Gorges M, Whyte SD. Anesthetic-sparing effect of dexmedetomidine during total intravenous anesthesia for children undergoing dental surgery: A randomized controlled trial. Paediatr Anaesth. 2024 Dec;34(12):1213-1222. doi: 10.1111/pan.14987. Epub 2024 Aug 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.25 ug/kg	Intravenous
Subject	Dexmedetomidine	Other / unclassified	0.5 ug/kg	Intravenous
Subject	Dexmedetomidine	Other / unclassified	1 ug/kg	Intravenous

Indications

No indication recorded.